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1.
Mil Behav Health ; 6(1): 102-107, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29545975

RESUMO

National military and veteran service organizations (MVSOs) have the potential to be advocates for stronger military tobacco control. This study consisted of qualitative analysis of interviews with 5 MVSO leaders (or their designees) and 6 focus groups conducted with veterans, to explore the opinions of MVSO leaders and veterans about military tobacco use and tobacco control policy, and to assess their current knowledge, attitudes, and likelihood of engaging with civilian tobacco control. Themes discussed include the impact of tobacco use on the military mission and on veterans; the possibility of stronger military tobacco control policies; and the idea that such policies would affect the rights of military personnel. Participants considered whether tobacco use impacts the military mission in the most literal sense (e.g., giving away patrol locations), ignoring larger scale effects on long term health and costs. While familiar with tobacco's impacts on veterans' health, MVSO leaders did not endorse stronger policies, although some veterans did. Participants were largely unaware of the impact of tobacco use on military readiness. Establishment of better alliances among MVSOs and civilian public health groups for mutual education about tobacco's many negative effects on the military's mission may be necessary to achieve a tobacco-free military.

2.
Occup Med (Lond) ; 67(1): 61-63, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27694377

RESUMO

BACKGROUND: No data exist on obesity or the accuracy of body mass index (BMI) in Russian Federation firefighters. AIMS: To determine the prevalence of obesity and rates of misclassification of BMI-based obesity status. METHODS: Career firefighters in the Moscow region completed anthropometric assessments including height, weight, BMI, body fat per cent (BF%) and waist circumference (WC). Using these three methods, we defined obesity as BMI ≥30, BF% >25 and WC >102, respectively. RESULTS: The study group consisted of 167 male firefighters. Obesity prevalence was 22% for BMI [95% confidence interval (CI) 16.9-28.5], 60% for BF% (95% CI 52.5-67.3) and 28% for WC (95% CI 21.3-34.9). False positive rates for BMI-based obesity status were low, with 3% (95% CI -1.1 to 7.1) and 6% (95% CI 1.6-9.9) of non-obese participants defined by BF% and WC standards misidentified as obese using BMI. However, 65% (95% CI 55.7-77.4) of BF%-defined obese participants and 36% (95% CI 22.5-49.9) of WC-defined obese participants were misclassified as non-obese using BMI (i.e. false negatives). CONCLUSIONS: Rates of BMI-based obesity in Russian male firefighters were similar to that of males in the general Russian adult male population. Compared with BF% or WC standards, BMI-based obesity classi- fication produced low rates of false positives but demonstrated high rates of false negatives.


Assuntos
Índice de Massa Corporal , Bombeiros/estatística & dados numéricos , Obesidade/epidemiologia , Prevalência , Tecido Adiposo , Adulto , Humanos , Masculino , Pessoa de Meia-Idade , Moscou/epidemiologia , Circunferência da Cintura
3.
Occup Med (Lond) ; 64(4): 246-54, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24711630

RESUMO

BACKGROUND: Obesity is of increasing concern especially among firefighters. Bias in self-reported body weight, height and body mass index (BMI) has received a great deal of attention given its importance in epidemiological field research on obesity. AIMS: To determine the validity of self-reported weight, height and BMI and identify potential sources of bias in a national sample of US firefighters. METHODS: Self-reported and measured weight and height (and BMI derived from them) were assessed in a national sample of 1001 career male firefighters in the USA and errors in self-reported data were determined. RESULTS: There were 1001 participants. Self-reported weight, height and BMI were significantly correlated with their respective measured counterparts, i.e. measured weight (r = 0.990; P < 0.001), height (r = 0.961; P < 0.001) and BMI (r = 0.976; P < 0.001). The overall mean difference and standard deviation between self-reported weight, height and BMI were 1.3±2.0kg, 0.94±1.9cm and 0.09±0.9kg/m(2), respectively, for male firefighters. BMI-based weight status (P < 0.001) was the most consistent factor associated with bias in self-reported BMI, weight and height, with heavier firefighters more likely to underestimate their weight and overestimate their height, resulting in underestimated BMIs. Therefore, using self-reported BMI would have resulted in overestimating the prevalence of obesity (BMI ≥ 30.0) by 1.8%, but underestimating the prevalence of more serious levels of obesity (Class II and III) by 1.2%. CONCLUSIONS: Self-reported weight and height (and the resulting BMI) were highly correlated with measured values. A primary and consistent source of error in self-reported weight, height and BMI based on those indices was BMI-based weight status.


Assuntos
Estatura , Índice de Massa Corporal , Peso Corporal , Bombeiros , Obesidade , Autorrelato , Percepção de Tamanho , Adulto , Viés , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade/epidemiologia , Prevalência , Reprodutibilidade dos Testes , Fatores Sexuais , Inquéritos e Questionários , Estados Unidos , Adulto Jovem
4.
Obesity (Silver Spring) ; 21(8): 1505-8, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23512940

RESUMO

OBJECTIVE: Firefighting is a dangerous profession with high injury rates, particularly musculoskeletal (MS), but limited longitudinal data is available to examine predictors of MS injuries in this population. DESIGN AND METHODS: The relationship between personal individual, nonoccupational factors (e.g., demographic characteristics, body composition, fitness, and health behaviors) and incident injury and incident MS injury in a prospective cohort of 347 firefighters from the central United States was examined. RESULTS: Baseline weight status was a significant predictor of incident MS injury, with obese (BMI ≥ 30 kg m(-2)) firefighters 5.2 times more likely (95% CI = 1.1-23.4) to experience a MS injury than their normal weight (BMI = 18.5-24.9 kg m(-2)) colleagues over the course of the study. Similarly, firefighters who were obese based on WC (>102.0 cm) were almost three times as likely (OR = 2.8, 95% CI = 1.2-6.4) to have a MS injury at follow-up. CONCLUSIONS: Findings highlight the importance of focusing on firefighters' body composition, nutrition and fitness as a means of decreasing risk for injury.


Assuntos
Doenças Musculoesqueléticas/epidemiologia , Obesidade/epidemiologia , Traumatismos Ocupacionais/epidemiologia , Adulto , Composição Corporal , Índice de Massa Corporal , Feminino , Bombeiros , Comportamentos Relacionados com a Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Atividade Motora , Doenças Musculoesqueléticas/complicações , Obesidade/complicações , Estudos Prospectivos , Fatores de Risco , Estados Unidos/epidemiologia , Circunferência da Cintura
5.
Occup Med (Lond) ; 63(3): 227-30, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23266431

RESUMO

BACKGROUND: Overweight, obesity and weight gain are significant problems in the U.S. fire service. While classification of obesity using body mass index (BMI) has demonstrated accuracy and low rates of false positives when compared with body fat percentage (BF%)-based standards, no studies have examined the accuracy of BMI-based overweight and normal weight status with other comparable body composition indices. AIMS: To compare overweight and normal weight BMI categories with BF% standards from the American Council on Exercise and analogous waist circumference (WC) categories and to examine rates and types of misclassification in fire fighters. METHODS: Data were collected from 11 randomly selected career fire departments in the International Association of Fire Chief's Missouri Valley Region. Demographics, occupational history, and body composition indices (weight, BF% and WC) were obtained from male career fire fighters who were categorized as normal weight or overweight based on BMI. RESULTS: There were 293 participants of whom 92 had normal BMI. There were low rates of false positives (12%) and moderate rates of false negatives (22%) when comparing BMI categories to the compar able BF% categories. However, using WC as the standard resulted in very high rates of false positives (63%) and very low rates of false negatives (5%). CONCLUSIONS: BMI-based overweight status was associated with significant errors in classification depending on the standard to which it was compared.


Assuntos
Índice de Massa Corporal , Bombeiros , Sobrepeso/diagnóstico , Adulto , Erros de Diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Padrões de Referência , Estados Unidos , Circunferência da Cintura , Adulto Jovem
6.
Occup Med (Lond) ; 62(8): 661-4, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23064207

RESUMO

BACKGROUND: Although the US National Fire Service is concerned about alcohol use among firefighters, little research has been conducted on the topic. AIMS: To survey alcohol use patterns among career and volunteer firefighters. METHODS: Data were from a population-based cohort study of male firefighters conducted in randomly selected career and volunteer departments. Data were collected from 2008 to 2010. RESULTS: There were 656 participants from 11 career and volunteer 13 departments included in the study with a response rate of 97%. Career firefighters drank approximately 10 days per month (just about half of their off duty days) and drank relatively heavily on those days. Fifty-eight per cent of career and 40% of volunteer firefighters averaged three or more drinks and similar percentages reported binge drinking on the days they consumed alcohol. In general, firefighters who drank but did not binge drink tended to have the best health outcomes, while those who binge drank typically were at highest risk of negative health outcomes. Nine per cent of career and 10% of volunteer firefighters who drank self-reported driving while intoxicated in the previous 30 days. CONCLUSIONS: Given the high rates of heavy and binge drinking, local and nationally coordinated efforts to increase the surveillance of drinking behaviour among firefighters and the development of targeted prevention interventions are critically needed.


Assuntos
Consumo de Bebidas Alcoólicas/epidemiologia , Bombeiros/estatística & dados numéricos , Adulto , Consumo Excessivo de Bebidas Alcoólicas/epidemiologia , Estudos de Coortes , Colorado/epidemiologia , Bombeiros/psicologia , Humanos , Masculino , Meio-Oeste dos Estados Unidos/epidemiologia
7.
Eat Weight Disord ; 16(4): e242-9, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22526130

RESUMO

Overweight and obesity are considered a serious health problem in Thailand. This study examined the prevalence of overweight and obesity in a nationally representative sample of Thai children and adults based on international standards. A cross-sectional population survey of 16,596 Thais aged 3 years and over was conducted. Heights and weights were obtained using standardized methods. Estimates of the overweight and obesity prevalence in children, adolescents, and adults were computed. The prevalence of overweight and obesity among children and adolescents aged 3 to 18 years was 7.6% and 9.0%, respectively, and was higher among boys than girls. Among adults, using the the Regional Office for the Western Pacific (WPRO) standard, 17.1% of adults were classified as overweight [body mass index (BMI) 23.0-24.9 kg/m²], 19.0% as class I obesity (BMI 25.0-29.9 kg/m²), and 4.8% as class II obesity (BMI ≥ 30.0 kg/m²). Using the World Health Organization (WHO) definition, 19.0% were overweight (BMI 25-29.9 kg/m²), 4.0% class I obesity (BMI 30.0-34.9 kg/m²), 0.8% class II obesity (BMI 35.0-39.9 kg/m²), and 0.1% class III obesity (BMI ≥ 40.0 kg/m²). There was a vast difference in obesity prevalence between the WHO and the WPRO criteria. Obesity prevalence when using the WPRO definition (23.8%) was almost five times greater than when defined with the WHO standard (4.9%). The present study found a high prevalence of overweight and obesity in nationally representative sample of the Thai population. Higher rates of overweight and obesity prevalence were computed using the WPRO standard when compared to the WHO standard.


Assuntos
Sobrepeso/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Povo Asiático , Índice de Massa Corporal , Criança , Pré-Escolar , Estudos Transversais , Ingestão de Alimentos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos Nutricionais , Obesidade/epidemiologia , Prevalência , Tailândia/epidemiologia
8.
Eat Weight Disord ; 13(2): 95-101, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18612258

RESUMO

PURPOSE: To evaluate the long-term impact of Medifast meal-replacement supplements (MMRS) combined with appetite suppressant medication (ASM) among participants who received 52 weeks of treatment. METHODS: We conducted a systematic program evaluation of weight loss data from a medically-supervised weight control program combining the use of MMRS and ASM. Data were obtained and analyzed from 1,351 patient (BMI> or =25) medical charts who had participated for at least 12 weeks of treatment. Outcomes included weight loss (kg) and percent weight loss from baseline and at 12, 24, and 52 weeks. Both completers and intention-to-treat analyses were conducted. Completers' (i.e., those with complete data for 52 weeks) outcomes were evaluated after stratification for reported adherence to the MMRS and ASM. RESULTS: Participants who completed 52 weeks of treatment experienced substantial weight losses at 12 (-9.4+/-5.7 kg), 24 (-12.0+/-8.1 kg), and 52 weeks (-12.4+/-9.2 kg) and all measures were significantly different from baseline weight (p<0.001 for all contrasts) for both true completers (n=324) and for ITT analysis (n=1,351). Fifty percent of patients remained in the program at 24 weeks and nearly 25% were still participating at one year. CONCLUSIONS: This weight loss program using a combination of MMRS and ASM produced significant and sustained weight losses at 52 weeks. Results were better than those typically reported for obesity pharmacotherapy in both short- and long-term studies and also better than those reported for partial meal replacement programs. Program retention at one year was similar to that reported in many controlled drug trials and better than most commercial programs reported in the literature.


Assuntos
Depressores do Apetite/uso terapêutico , Alimentos Formulados , Obesidade/terapia , Adulto , Índice de Massa Corporal , Terapia Combinada , Preparações de Ação Retardada , Relação Dose-Resposta a Droga , Esquema de Medicação , Feminino , Seguimentos , Humanos , Masculino , Morfolinas/uso terapêutico , Pacientes Desistentes do Tratamento , Fentermina/uso terapêutico , Redução de Peso/efeitos dos fármacos
9.
J Intern Med ; 260(4): 388-98, 2006 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-16961676

RESUMO

OBJECTIVE: There is a significant need for an obesity treatment model suitable for the primary care environment. We examined the effectiveness of a brief counselling intervention alone, in combination with orlistat, and drug-alone in a 12-month randomized-clinical trial at a medical school obesity centre. METHODS: Participants (N = 250) with body mass index (BMI) >or=27 were randomized. Changes in body weight, lipids, blood pressure and serum glucose were examined. Drug adherence and attendance were also evaluated. RESULTS: Completers analysis was conducted on 136 participants with data at baseline, 6 and 12 months and intention-to-treat analyses (ITT) for the total sample. Amongst completers, participants in the drug only (P = 0.012) and drug + brief counselling (P = 0.001) groups lost more weight (mean +/- SD: -3.8 +/- 5.8 kg and -4.8 +/- 4.4 kg, respectively) than participants in the brief counselling only group at 6 months (-1.7 +/- 3.3 kg), but there were no significant group differences at 12 months. ITT model results were similar to completers at 6 months and remained significant at 12 months, but the weight losses were more modest (<3 kg) for both groups receiving orlistat. For brief counselling alone, participants gained weight (1.7 +/- 4.2 kg). Cardiovascular disease (CVD) parameter changes were negligible. CONCLUSIONS: Pharmacotherapy alone or combined with brief counselling resulted in modest weight losses that had minimal impact on cardiovascular parameters, but were greater than brief counselling alone. Whilst brief interventions and primary pharmacotherapy have been suggested as viable treatments for implementation in primary care settings, our study suggests that such minimal interventions provide minimal benefits.


Assuntos
Fármacos Antiobesidade/uso terapêutico , Aconselhamento/métodos , Lactonas/uso terapêutico , Obesidade/terapia , Atenção Primária à Saúde/métodos , Adulto , Doenças Cardiovasculares/etiologia , Humanos , Estilo de Vida , Pessoa de Meia-Idade , Obesidade/tratamento farmacológico , Orlistate , Cooperação do Paciente , Pacientes Desistentes do Tratamento , Fatores de Risco , Resultado do Tratamento , Redução de Peso/fisiologia
10.
Eat Weight Disord ; 11(1): e35-41, 2006 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16801738

RESUMO

AIMS: To investigate the effects of a pharmacotherapy (orlistat) plus lifestyle management (OLM) intervention on weight loss in Mexican American women with and without metabolic syndrome (MS). METHODS: One hundred and seven female participants aged 21-65 years and of Mexican origin were randomized to either OLM or a wait-list control group (WLC) for one year. The lifestyle interventions were tailored to exhibit features of the Mexican culture. Within each group, subjects with MS were compared to those without MS to assess whether its presence mitigates weight loss. Risk factors for MS also were assessed. RESULTS: Participants with MS in the OLM group experienced significant decreases in weight and body mass index (BMI) as compared to participants without MS. Participants with MS in the OLM group and who completed the study lost 9.3+/-7.5 kg (20.5+/-16.5 lb) as compared to participants with MS in the WLC group, who only lost 0.2+/-3.1 kg (0.4+/-6.8 lb). Further, participants with MS in the OLM group who completed the study experienced a 3.1+/-3.9 kg/m2 decrease in BMI whereas participants with MS in the WLC group only experienced a 0.1+/-1.2 kg/m2 decrease in BMI. No changes in other MS risk factors were significant. CONCLUSIONS: Patients with MS experienced significant weight loss and decreases in BMI as a result of a lifestyle and pharmacotherapy intervention.


Assuntos
Fármacos Antiobesidade/uso terapêutico , Exercício Físico , Lactonas/uso terapêutico , Síndrome Metabólica/terapia , Obesidade/terapia , Adulto , Idoso , Índice de Massa Corporal , Terapia Combinada , Feminino , Humanos , Estilo de Vida , Síndrome Metabólica/sangue , Síndrome Metabólica/etnologia , Americanos Mexicanos , Pessoa de Meia-Idade , Obesidade/sangue , Obesidade/etnologia , Orlistate , Sobrepeso , Fatores de Risco , Redução de Peso
11.
Addict Behav ; 31(12): 2313-8, 2006 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-16564137

RESUMO

In developing nations where reductions in tobacco use have not been realized, it is critical that health professionals be encouraged to abstain from tobacco use. Data on tobacco use among health professionals in India are limited. We conducted cross-sectional surveys among 110 male medical school faculty (MSF), 229 physicians (67% male), 1130 medical students (46% male), and 73 female nursing students. Information on tobacco use and quit attempts was collected using structured questionnaires. Among the male respondents, current smokers were 15.1% of MSF, 13.1% of physicians, and 14.1% of medical students. Among current smokers, 42% of MSF and physicians and 51% of medical students had not attempted quitting in the last year. However, one third of MSF and physicians and 16% of medical students had attempted to quit at least 4 times. This is one of the first studies among health care professionals in India. Our findings show that a substantial proportion of physicians and medical students in Kerala continue to smoke. Smoking cessation programs are warranted in medical schools in Kerala. An initiative is presently underway by the authors to incorporate tobacco education into the medical school curriculum.


Assuntos
Pessoal de Saúde/psicologia , Fumar/epidemiologia , Adulto , Estudos Transversais , Docentes de Medicina , Feminino , Inquéritos Epidemiológicos , Humanos , Índia/epidemiologia , Masculino , Abandono do Hábito de Fumar , Estudantes de Medicina/psicologia , Estudantes de Enfermagem/psicologia
12.
J Phys Act Health ; 3(4): 405-414, 2006 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28834496

RESUMO

BACKGROUND: Basic information is needed to develop strategies for promoting physical activity (PA) in small business. This preliminary study described small business policies encouraging PA. METHODS: Interviews were completed at 98 small businesses (5-100 employees) in 2003. Business policies encouraging PA participation by employees and the public were assessed. Stage of Change was used to describe intentions to develop such policies. RESULTS: A total of 53 PA policies (12 employee; 41 public) existed. The most common employee policy was incentives for gym memberships (41.7%). The most popular public policy was sport team sponsorships (60.1%). Most businesses (60.2%) were not thinking about creating a policy for PA while 33.7% had a policy in place (20.4% > 6 months). CONCLUSION: Small businesses have few PA policies and most are not thinking about such policies. Research should determine why this is the case and what approaches could stimulate the development of PA policies.

13.
Int J Obes (Lond) ; 29(9): 1107-14, 2005 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-15925955

RESUMO

OBJECTIVE: To evaluate whether snacking would improve weight loss and weight maintenance in overweight individuals within the context of a structured meal replacement (MR) weight loss program. DESIGN: A prospective 24 week, 2 (snacking vs nonsnacking) x 2 (MR vs meal replacement augmented with snacks (MRPS)) randomized trial. Participants were instructed to limit their total daily intake to 1200 (women) or 1500 (men) kcals. Those receiving the MR program were instructed not to snack while those in the MRPS program were told to snack three times per day. SUBJECTS: A total of 100 participants were block-randomized, based on prestudy snacking status (high vs low), to receive a standard meal replacement program (MR) or MRPS. MEASUREMENTS: Weight, height, blood pressure, lipid fractions, glucose, and insulin were assessed at the baseline, 12-, and 24 weeks. RESULTS: Completers analysis at 24 weeks demonstrated a significant time effect (F(1,46)=44.6, P<0.001), indicating that all participants lost significant amounts of weight regardless of group assignment. An intention-to-treat model resulted in similar results. By week 24, the average weight loss across groups was 4.6 kg. There also were significant improvements across all groups among completers for systolic blood pressure (P=0.047), cholesterol (P=0.001), LDL (P=0.001), glucose (P=0.004), and insulin (P=0.001) at week 12, and glucose (P=0.001) and insulin at week 24 (P=0.003). CONCLUSIONS: Our results suggest that a participant's preferences for snacking did not affect their response to treatment. Snackers and nonsnackers responded equally well whether they received a standard meal replacement program or one augmented with snacks.


Assuntos
Ingestão de Alimentos/fisiologia , Ingestão de Energia/fisiologia , Sobrepeso/fisiologia , Redução de Peso/fisiologia , Adulto , Glicemia/análise , Pressão Sanguínea , Colesterol/sangue , Comportamento Alimentar/fisiologia , Feminino , Humanos , Insulina/sangue , Masculino , Pessoa de Meia-Idade , Obesidade/sangue , Obesidade/prevenção & controle , Cooperação do Paciente , Estudos Prospectivos , Fatores de Tempo , Resultado do Tratamento
14.
Disabil Rehabil ; 24(6): 334-40, 2002 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-12017467

RESUMO

PURPOSE: Investigators have examined factors that predict treatment outcome and disability status in chronic pain patients, including psychopathology and personality characteristics with equivocal results. The purpose of this study was to evaluate the usefulness of personality characteristics, depression, and personality disorders in predicting disability status in pain patients with long-term follow-up. The setting was a rehabilitation hospital in Southern Sweden. METHOD: Subjects were 184 pain patients (mean age = 43.4 (10.8) years; 72.8% female) who had no more than 365 sick leave days (Mean sick leave days = 132.7 (128.2)) prior to the baseline personality and psychiatric evaluation. The baseline evaluation consisted of a psychiatric interview that included the administration of the Structured Clinical Interview for DSM-IV Screen Questionnaire (SCID-II), the Montgomery-Asberg Depression Rating Scale (MADRS), and the Karolinska Scales of Personality (KSP). Disability status was assessed by insurance record review a minimum of two-and-a-half years after baseline evaluation. RESULTS: Multivariate logistic regression suggests that age (OR = 1.09, 95% CI = 1.02-1.18; p = 0.013), number of sick leave days prior to evaluation (OR= 1.01, 95% CI= 1.01-1.02; p = 0.018), and baseline diagnosis of depression significantly predicted subsequent disability status (OR = 7.04, 95% CI = 1.15-42.93; p = 0.034). Baseline personality traits and the diagnosis of a personality disorder were not useful predictors of disability status in our sample. CONCLUSIONS: These data suggest that depression, but not personality disorders characteristics, was an important disability predictor in chronic pain patients with extended follow-up.


Assuntos
Depressão/etiologia , Pessoas com Deficiência , Dor/fisiopatologia , Adulto , Doença Crônica , Feminino , Humanos , Entrevista Psicológica , Masculino , Dor/complicações , Dor/psicologia , Personalidade , Prognóstico
15.
Eat Weight Disord ; 7(1): 68-71, 2002 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11930987

RESUMO

The G-protein beta3 subunit 825 TT genotype has been associated with obesity and hypertension. We examined the interaction between the G-protein TT genotype, physical activity and body mass index (BMI) in a cross-sectional study of African immigrants and African Americans. The genotype frequencies were 6.3% CC, 37.7% CT, and 56% TT. After adjusting for potential confounders, BMI was found to be significantly higher in the sedentary than in the physically active participants (p=0.045). There was no statistically significant effect for genotype (p=0.215) or the interaction between genotype and the level of physical activity (p=0.219). However, the individuals with the CC or CT genotype who were physically active had substantially lower BMIs (M+/-SE) (i.e., 25.74+/-2.02) than any of the other groups: sedentary CC + CT (30.58+/-1.03), sedentary TT (30.65+/-1.00) or active TT (29.43+/-1.65). Because of the low statistical power of this study, further research is needed to confirm these findings and to explore potential gene-environment/lifestyle interactions.


Assuntos
População Negra/genética , Exercício Físico , Proteínas de Ligação ao GTP/genética , Predisposição Genética para Doença/genética , Obesidade/genética , Adulto , Índice de Massa Corporal , Estudos Transversais , Feminino , Humanos , Masculino , Inquéritos e Questionários
16.
Int J Obes Relat Metab Disord ; 26(2): 262-73, 2002 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-11850760

RESUMO

AIM: This article provides the first comprehensive meta-analysis of randomized clinical trials of medications for obesity. METHOD: Based on stringent inclusionary criteria, a total of 108 studies were included in the final database. Outcomes are presented for comparisons of single and combination drugs to placebo and for comparisons of medications to one another. RESULT: Overall, the medications studied produced medium effect sizes. Four drugs produced large effect sizes (ie d>0.80; amphetamine, benzphetamine, fenfluramine and sibutramine). The placebo-subtracted weight losses for single drugs vs placebo included in the meta-analysis never exceeded 4.0 kg. No drug, or class of drugs, demonstrated clear superiority as an obesity medication. Effects of methodological factors are also presented along with suggestions for future research.


Assuntos
Fármacos Antiobesidade/uso terapêutico , Obesidade/prevenção & controle , Anfetaminas/uso terapêutico , Benzfetamina/uso terapêutico , Ciclobutanos/uso terapêutico , Fenfluramina/uso terapêutico , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto
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