RESUMO
The quality of life in hospital at home has been very little described. In the "Feel'HAD" study, 488 patients completed an EQ-5D-3L questionnaire during a nursing visit. Neurological and geriatric pathologies were found to be the most degraded, even if there were strong disparities within the different types of conditions. This work has shown that beyond technical care, some people need more support, psychological care, comfort or social support. It led to concrete improvements in our practices and demonstrated that large-scale research is possible in the home.
Assuntos
Qualidade de Vida , Idoso , Humanos , Inquéritos e QuestionáriosRESUMO
There is a large body of data to support the use of an inhaled corticosteroid (ICS) plus a long-acting beta(2)-agonist vs. increasing the dose of ICS in adults, but less data in children. This double-blind, parallel group, non-inferiority study compared lung function and asthma control, based on Global Initiative for Asthma guidelines, in children receiving either salmeterol/fluticasone propionate (SFC) 50/100 microg bd (n = 160) or fluticasone propionate (FP) 200 microg bd (n = 161) for 12 wks. Change from baseline in mean morning peak expiratory flow increased following both treatments, but was significantly greater in the SFC group compared with FP [Adjusted mean change (s.e.) (l/min): SFC: 26.9 (2.13), FP: 19.3 (2.12); treatment difference: 7.6 (3.01); 95% CI: 1.7, 13.5; p = 0.012)]. Asthma control improved over time in both groups. Mean pre-bronchodilator maximal-expiratory flow at 50% vital capacity and percentage rescue-free days showed significantly greater improvements in the SFC group compared with FP. All other efficacy indices showed comparable improvements in each group. Treatment with SFC 50/100 microg bd compared with twice the steroid dose of FP (200 microg bd), was at least as effective in improving individual clinical outcomes and overall asthma control, in asthmatic children previously uncontrolled on low doses of ICS.
