RESUMO
The influence of the DNA repair gene PSO3 on photoactivated psoralen-induced meiotic recombination, gene conversion, reverse mutation, and on survival, was assayed in diploid strains of Saccharomyces cerevisiae homozygous for the wild-type or the pso3-1 mutant allele. Sporulation was normal in the pso3-1 diploid. Wild-type and mutant strains had the same sensitivity to photoactivated monofunctional psoralen (3-CPs + UVA) in meiosis-uncommitted and meiosis-committed stages. The mutant showed higher sensitivity to photoactivated bifunctional psoralen (8-MOP + UVA) during all stages of the meiotic cycle. Mutation induction by 3-CPs + UVA or 8-MOP + UVA in meiosis-committed cells revealed no significant differences between wild-type and the pso3-1 mutant. The status of the PSO3 gene has no influence on the kinetics of induction of gene conversion and crossing-over after 3-CPs + UVA treatment in meiosis-committed cells: gene conversion was blocked while recombination was induced. After treatment with 8-MOP + UVA gene conversion was also blocked in both strains while crossing-over could only be observed in meiosis-committed wild-type cells.
Assuntos
Furocumarinas/farmacologia , Genes Fúngicos/efeitos dos fármacos , Saccharomyces cerevisiae/genética , Reparo do DNA/genética , Furocumarinas/efeitos da radiação , Conversão Gênica , Meiose/efeitos dos fármacos , Meiose/genética , Mutagênese , Mutação , Recombinação Genética , Saccharomyces cerevisiae/efeitos dos fármacos , Saccharomyces cerevisiae/metabolismo , Esporos Fúngicos/efeitos dos fármacos , Esporos Fúngicos/genética , Raios UltravioletaRESUMO
Complete or partial dislocation of the temporomandibular joint occurs readily in some patients. Some patients may have a history of recurrent dislocation. Dislocation may also be caused by injudicious use of mouth gags. If it occurs it should be reduced immediately
Assuntos
Luxações Articulares , Transtornos da Articulação TemporomandibularRESUMO
The first reported practice of Dentistry by an unqualified operator is that of a Mr Cocotte in South Mahe. He used to go from door to door enquiring if there any children needing extractions. Armed with a pair of forceps and a towel on which to wipe them; he charged five cents a tooth. Tradionally; local treatment for toothhache made use of the coconut and the cinnamon trees
Assuntos
Cárie Dentária/tratamento farmacológico , Serviços de Saúde Bucal/história , Serviços de Saúde Bucal/tendências , MedicinaRESUMO
The Seychelles dental service forms part of the primary health care division of the Ministry of Health. It promotes the oral health of the people by giving effect to the policies of the Ministry and Government. It is worthwhile examining in some detail the meaning of oral health of all people. The implications are extensive. It requires an all embracing dental service to be offered to the public
