Assuntos
Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Diuréticos/uso terapêutico , Indapamida/uso terapêutico , Perindopril/uso terapêutico , Relação Dose-Resposta a Droga , Quimioterapia Combinada , Feminino , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Fluxo Pulsátil/efeitos dos fármacosRESUMO
We report here the second case of Candida utilis infection in humans. The patient was apparently immunocompetent, had no central catheter, and survived an 8-day fungemia. Genomic analysis confirmed the conspecificity of medical and industrial strains of C. utilis and that of the anamorphic yeast C. utilis with the teleomorphic yeast Pichia jadinii.
Assuntos
Candida/isolamento & purificação , Candidíase/microbiologia , Fungemia/microbiologia , Idoso , Anfotericina B/uso terapêutico , Candida/genética , Candida/patogenicidade , Candidíase/tratamento farmacológico , Candidíase/etiologia , DNA Fúngico/genética , Fungemia/tratamento farmacológico , Fungemia/etiologia , Humanos , Masculino , VirulênciaRESUMO
Major ventricular repolarization disorders without evidence of myocardial infarction developed in 2 patients during the first course of a 5-fluorouracil (5-FU) treatment in doses of 1,000 mg/m2/day. Anginal pain was present in one patient but not in the other. The electrical abnormalities persisted for more than 6 weeks in one case. Explorations carried out 2 and 6 weeks later respectively under calcium inhibitors showed absence of coronary artery stenosis, negative methyl ergonovine test (even after 5-FU infusion in one patient) and normal left ventricular kinetics. The mechanism of cardiac toxicity is discussed on the basis of these data: some elements support a coronary spasm and others direct myocardial toxicity.
Assuntos
Fluoruracila/intoxicação , Cardiopatias/induzido quimicamente , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Brônquicas/tratamento farmacológico , Carcinoma de Células Escamosas/tratamento farmacológico , Cisplatino/uso terapêutico , Eletrocardiografia , Fluoruracila/uso terapêutico , Cardiopatias/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/tratamento farmacológicoRESUMO
The increasing alcohol consumption throughout the world appears to constitute an enduring public health problem. In developing countries, the consequences of such consumption should be considered as questions of both classical alcohol-linked pathology and of food balance. Available data for 3 countries in Africa (Burkina Faso, Congo, Cameroons) show an important growth in the industrial production of alcoholic beverages (mostly beer) over the last 20 years, while variation in traditional home production remains unknown. However, the lack of data on consumption does not permit a good appreciation of this problem.
