[Blood serum concentration of lipids and lipoproteins and body composition].

The purpose of this study is the analysis of the relationship of blood serum apolipoprotein E (apoE), total cholesterol (TC), triglycerides (TG) and high-density and low-density lipoproteins (HDL, LDL), with body mass index (BMI), relative body surface area (RBSA) and body muscle (BM) and body fat (BF). The subjects are males and females aged 14-16 (adolescent age group 1: n1M = 141, n1F = 151) and 18-25 (young adult group 2, n2M = 16, n2F = 46). Significant correlations of serum TG and HDL with somatometric indicators were not observed. In the female samples, TC content directly correlates (p < 0.05) with BF (r1 = 0.164; r2 = 0.418) and negatively correlates with BM (r1 = -0.165; r2 = -0.352). The blood serum concentration of apoE is significantly correlated with body composition in adolescent females (for BF r1 = -0.168; for BM r1 = 0.266; p < 0.05); in males 14-16 years old, the both correlations have a significance level p < 0.06. In young adult females TC and LDL content negatively correlates with RBSA (r2 = -0.386 and -0.377 respectively; p < 0.05) and positively correlates with BMI (r2 = 0.413 and 0.415 respectively; p < 0.05). Adolescent females and young adult females have opposite relationships between FC and apoE concentration. In females 14-15 years old apoE concentration decreases as FC increases. In females 16-17 the correlation disappears, and in older females apoE concentration and FC increase together.

[Influence of latitude factor on organism of adolescences residing on North].

Complex investigations of adolescences (14-15 years) residing on the European North at 62 and 65 degrees latitudes have been carried out. It was shown that the latitude factor on the North affected on mature organism of adolescences already at a difference of residence place on 3 degrees. The decrease of tolerance to hypoxemia, quality of hemodynamic regulation at short-term physical activity, physical health level, nervous processes rate (switching of attention) and the increase of plasma lactate level (attribute of hypoxia) were shown in adolescences residing at higher latitudes. The sexual distinctions and features of northerner organism on a lot of parameters in adolescences were revealed.

[Serum glucose level in acute severe hypoxia in human at rest].

Study of the effects of acute normobaric hypoxia was performed on a group of young healthy males (age 19-23, n = 10). Conditions of acute normobaric hypoxia were modeled by using oxygen-nitrogen mixture containing 8% of oxygen as a breath gas. That level of oxygen corresponds with its partial pressure at 7000 meters above sea level. A number of different analyses were conducted during experiment: levels of glucose, pyruvate, lactate in peripheral venous blood, hemoglobin, pH, hematocrit, partial pressures of 02 and CO2, hemoglobin saturation. It was shown that on 5th minute of hypoxia serum glucose level decreased significantly (p < 0.05). The average decrease was about 0.76 mmol/l in its maximum and lowest individual glucose levels were 4.0 mmol/l or higher. Serum glucose level returned to background values (assessed before the test) at 10th minute of experiment. In our opinion results of the study suggest that syncopal form of height hypoxia may be caused by the reasons other than hypoglycemia.

[Fatty acid of human plasma under the influence of acute strong normobaric hypoxia].

The influence of acute normobaric hypoxia on total pool of human plasma fatty acids was studied in experiment (respiration of hypoxic gas mixture containing 8% of O2, during 25 min). Health status of participants-volunteers and the hypoxia intensity were monitored with a complex of electrophysiological methods: EEC, ECG, measurement of blood pressure, SpO2, evaluation of cardiac output, gas analysis of exhaled air. Using gas chromatography we studied plasma fatty acids total profile (esterificated and non-esterificated) before hypoxia exposure, on 2nd, 5th, 10th, 20th minutes of acute hypoxia and on 5th and 15th minutes of recovery. It was shown that blood saturation value dropped to 52.1 +/- 7.1 % on 25th minute of hypoxia exposure. There were no statistically significant changes in concentrations of total fatty acids, saturated fatty acids, monounsaturated palmitoleic acid, polyunsaturated linoleic and linolenic acids. Significant (p < 0.05) decrease of concentration of oleic and arachidonic acids was displayed that persisted after 15 minutes of recovery period. It is possible to assume that these changes in unsaturated fatty acid concentration were caused by activation of free radical oxidation processes and production of oleic acid derivatives. The performed hypoxic test seemed to be sufficient in order to reveal hypoxia effects on metabolism of individual unsaturated fatty acids.

[Thiamin and ribovlavin status in populations of Arkhangelsk].

It was been performed the epidemiological study of Thiamine and Riboflavin status of 3579 inhabitants in Arkhangelsk. Establish by 49.6% man and 47.4% woman have lower provision of thiamin. Lack of riboflavin reveal by 23.6% man and 21.7% woman. The analysis of the effect of seasonality on vitamins content shown the worst thiamin level in examined population in January-February and in September-October. The worst Riboflavin content observed in examined population in December-January and in July-August.