RESUMO
In the last 5 years we have seen six cases of bowel perforation during initial therapy for childhood non-Hodgkin's lymphoma (NHL). Perforation occurred only in patients with Stage III or IV disease. It occurred in patients without clinically detectable mural disease of bowel. Children who suffered bowel perforation had a worse outcome than those who did not, but two of the six patients described have gone on to long-term disease-free survival more than 2 years from completion of their treatment.
Assuntos
Neoplasias Abdominais/terapia , Doenças do Íleo/patologia , Perfuração Intestinal/patologia , Linfoma/terapia , Neoplasias Abdominais/complicações , Neoplasias Abdominais/patologia , Adolescente , Criança , Terapia Combinada , Daunorrubicina/uso terapêutico , Feminino , Humanos , Doenças do Íleo/etiologia , Perfuração Intestinal/etiologia , Laparotomia , Linfoma/complicações , Linfoma/patologia , Masculino , Neoplasias do Mediastino/terapia , Recidiva Local de Neoplasia , Neoplasias Peritoneais/terapia , Reoperação , Neoplasias Retroperitoneais/terapiaRESUMO
A blocking microcytotoxicity assay was used to detect soluble astrocytoma-associated antigen. The richest source of soluble antigen was found in spent culture media from an established glioblastoma (GF) tissue culture line. Also assayed were fractions of sonicated membrane antigen from another (GM) glioblastoma and pellets of GF and GM cultured glioblastoma tissue. Blocking by media conditioned by cultured normal human brain, breast cancer, neuroblastoma, meningioma, or 2-year-old astrocytoma cell lines was 41-82% lower. A monomer was isolated that blocked cytotoxicity and migrated in molecular exclusion chromatography with alpha-macroglobulins rather than the beta-2-microglobulins usually associated with histocompatibility antigens.
Assuntos
Anticorpos Antineoplásicos/análise , Antígenos de Neoplasias/análise , Astrocitoma/imunologia , Citotoxicidade Imunológica , Glioma/imunologia , Anticorpos Heterófilos/análise , Ligação Competitiva , Linhagem Celular , Cromatografia em Gel , Meios de Cultura , Testes Imunológicos de Citotoxicidade , Humanos , SonicaçãoRESUMO
From February 1975 to February 1977, 880 patients with acute lymphoblastic leukaemia were enrolled on Children's Cancer Study Group protocol 141 designed to evaluate prognostic factors and more intensive therapy for patients with poor prognosis. 765 diagnostic bone marrow aspirates from 23 institutions were available for classification using the French-American-British system. 60 of 615 patients with L1 morphology had vacuolated lymphoblasts. Patients with vacuolated lymphoblasts had a better disease-free survival (P = 0.14) and a significantly better survival (P = 0.03) but the presence of vacuoles was associated with a low initial WBC and an age range associated with improved prognosis for disease-free and over-all survival.
