Lasers in corneal surgery.

New laser methods have introduced new possibilities and partly replaced traditional methods in corneal surgery. Femtosecond lasers have traditionally been used to replace the surgeons' knife in corneal refractive surgery and corneal transplantation. Excimer laser has been used from the beginning of 1990 for the reshaping of cornea. With the development of excimer laser, traditional photorefractive corneal surgery has improved and new methods have been found such as PRK, PTK, epi-LASIK, and LASEK. Today LASIK, the most commonly used refractive surgery, uses both femtosecond and excimer lasers. SMILE, the most recent method in corneal refractive surgery, is solely based on the use of femtosecond laser.

VHS domain -- a longshoreman of vesicle lines.

The VHS (Vps-27, Hrs and STAM) domain is a 140 residue long domain present in the very NH2-terminus of at least 60 proteins. Based on their functional characteristics and on recent data on the involvement of VHS in cargo recognition in trans-Golgi, VHS domains are considered to have a general membrane targeting/cargo recognition role in vesicular trafficking. Structurally, VHS is a right-handed superhelix of eight helices with charged surface patches probably serving as sites of protein-protein recognition and docking.