RESUMO
The adjuvant effect of high-frequency hyperthermia of the abdominal cavity was studied in 2-month-old mice of highly leukemic AKR strain treated with cyclophosphamide. Weights of organs, parameters of the peripheral blood, and cytological imprints of organs were compared in experimental and control animals. A more pronounced antitumor effect was observed in animals exposed to hyperthermia. These data provide the basis for clinical use of hyperthermia of the abdominal cavity.
Assuntos
Cavidade Abdominal , Hipertermia Induzida , Leucemia Experimental/terapia , Animais , Terapia Combinada , Ciclofosfamida/uso terapêutico , Camundongos , Camundongos Endogâmicos AKR , Transplante de Neoplasias/patologia , Baço/citologiaRESUMO
Efficacy of splenectomy at initial stage of multimodality treatment of severe aplastic anemia was assessed in 25 patients aged 15-42. None of the patients achieved remission though there was a relief of hemorrhagic syndrome, diminished requirement in transfusion of donor platelets, a persistent rise in the counts of reticulocytes, leukocytes, absolute number of granulocytes in peripheral blood on postoperative days 14-21 and 60. All the patients were subsequently treated with immunodepressants.