RESUMO
A group of 70 patients with 181 previously failed cycles of in-vitro fertilization (IVF) (including intra-muscular administration of gonadotrophins) achieved ongoing pregnancy rates of 29.3% per started cycle when gonadotrophins were administered intravenously in a pulsatile fashion, during suppression with a gonadotrophin releasing hormone analogue. The ongoing pregnancy rates of 175 patients treated with gonadotrophins intramuscularly and who also had at least one previous failed IVF cycle and who were treated during the same period in the same IVF programme was 15.6% per started cycle. This rate was significantly lower than that in the group treated intravenously.
Assuntos
Fertilização in vitro , Menotropinas/administração & dosagem , Adulto , Feminino , Hormônio Liberador de Gonadotropina/administração & dosagem , Hormônio Liberador de Gonadotropina/análogos & derivados , Humanos , Bombas de Infusão , Injeções Intramusculares , Injeções Intravenosas , Fluxo PulsátilRESUMO
Success rates from in-vitro fertilization (IVF) in the long term are dependent on selection procedures with regard to continuation into further IVF episodes. Publications on success rates in successive episodes will give incentives to adapt selection criteria, but if these publications do not deal explicitly with patient selection, the adaptations might change their direction every time: the pendulum danger.
Assuntos
Fertilização in vitro , Pacientes Desistentes do Tratamento/estatística & dados numéricos , Feminino , Humanos , Gravidez , Prognóstico , Estudos Prospectivos , Análise de RegressãoRESUMO
Part of a cost-effectiveness study of in-vitro fertilization was the evaluation of the medical results of this fertility treatment. Data were prospectively collected from greater than 3000 IVF treatments in five Dutch hospitals during a 2-year period. The average 'take-at-least-one-healthy-baby-home-rate' per started treatment was 10% (the average clinical pregnancy rate per embryo transfer was 20%). After more IVF treatments, about one in three to four couples were successful. Differences in results were mainly caused by patient characteristics, the treatment episode and the treating hospital. These differences remained in a multivariate logistic regression analysis.
Assuntos
Fertilização in vitro , Análise Custo-Benefício , Feminino , Seguimentos , Humanos , Análise Multivariada , Países Baixos , Gravidez/estatística & dados numéricos , Estudos ProspectivosRESUMO
Part of a cost-effectiveness study on in-vitro fertilisation was the evaluation of the medical results of this fertility treatment. Data were prospectively collected from more than 3000 IVF treatments in the five Dutch hospitals during a two-year period. The average take-at-least-one-healthy-baby-home rate per started treatment was 10% (the average clinical pregnancy rate per embryo transfer was 20%). After several IVF treatments about one in three or four couples were successful. Ranges in results were mainly caused by patient characteristics, the individual treatment number and the treating hospital. Male subfertility and long-lasting and primary infertility result in a bad prognosis. Success rates differed substantially between hospitals, even after correction for patient mix.
