[Dietary habits of school children: breakfast]. / Indagini sulle abitudini alimentari di bambini in eta' scolare: la i colazione.

An investigation on the dietary habits of 944 secondary school children from Alghero, with reference to breakfast consumption and composition, has shown that the percentage of students who eat nothing for breakfast is higher than that reported by other authors. Furthermore it has been noted that consumption decreases among grown up students. Milk and coffee is the most common type of nutriment and also bread and biscuits are well represented. Other types of food, such as jam, yogurt or butter, are instead rarely consumed. Therefore the average caloric intake is of about 400 Kcal.

[Electrocardiogram changes in the rat by coenzyme A action]. / Modificazioni dell'elettrocardiogramma del ratto per azione del coenzima A.

The authors, having in a previous series of experiments observed that coenzyme A, administered intravenously in doses from 200 to 500 U.L., causes an immediate and transient decrease of the sinus rate, wanted to study to which part of the complex molecule of coenzyme A such effect is due. That's why they studied the action, intravenously, of pantothenic acid (200-400 mg/Kg), of cysteine (40-80 mg/Kg), of pantethein (40-100 mg/Kg) and of adenosine (4-10 mg/Kg). The results of the experiments demonstrate that the former bradycardia is due to adenosine, whereas the other substances have not this effect.

[Nutritional habits of homozygote beta-thalassemic subjects]. / Indagine sulle abitudini alimentari di soggetti beta-talassemici omozigoti.

An investigation on eating habits of a group of 40 patients with beta-thalassemia major has been carried out mainly to evidentiate iron intake whose absorption is strikingly increased in this disease. Questionnaires were used to obtain information. Daily food intake, the mean consumption of various types of food and the level of the more significant nutrients were calculated, using the National Institute of Nutrition tables. A high consumption of meat and a low consumption of fruits and vegetables were observed. A high proportion of proteins (particularly of animal origin) and a low proportion of lipids and carbohydrates was observed in comparison with the recommended levels of nutrients. Iron intake was slightly lower but its absorption may be increased because of the high proportion of calories of animal origin. A manipulation of the diet seems to be necessary to reduce the risk of iron loading.

Plasma lipids and lipoproteins pattern in beta-thalassemia major.

We studied serum lipids and lipoproteins in 20 patients with beta-thalassemia major, under high transfusion programme and regular chelation therapy, and in 20 control subjects. Total cholesterol, HDL-cholesterol, HDL2-and HDL3-cholesterol, apolipoprotein A and B levels were significantly lower in patients with Cooley's anemia, whereas free cholesterol, triglycerides and the HDL-/HDL3-cholesterol ratio did not differ in the two groups. We think that liver damage plays an important role in determining the altered lipoprotein pattern in beta-thalassemia major. However, other factors may contribute to cause such lipid changes.

[Experimental electrocardiography research. A study in the rat of the cardiovascular effects of verapamil]. / Ricerche di elettrocardiografia sperimentale. Studio nel ratto degli effetti cardiovascolari del verapamil.

Electrocardiographic changes induced by Verapamil, drug inducing inhibition of transmembrane movement of calcium into cardiac cells and mobilization of intracellular Ca++, have been studied in 10 anesthetized rats. Authors observed that Verapamil has: 1) negative chronotropic action on SA node; sometimes appears a superior nodal rhythm; 2) inconstantly, negative dromotropic action with prolonged atrioventricular conduction and "period of Luciani-Wenckebach'; 3) effective antiarrhythmic action; 4) no protective action towards peripheric vascular epinephrine effects; 5) remarkable negative inotropic action, whose Authors consider indirect signs the electrocardiographic changes, which indicate severe coronary failure, and the death of 6 rats by acute pulmonary edema.

[Experimental electrocardiographic research. Study in the rat of the cardiovascular effects of labetalol]. / Ricerche di elettrocardiografia sperimentale. Studio nel ratto degli effetti cardiovascolari del labetalolo.

Electrocardiographic changes induced by Labetalol, a drug blocking alpha- and beta-adrenergic receptors, have been studied in 10 anesthetized rats. Authors observed that Labetalol has: 1) slightly negative chronotropic action; 2)slightly negative dromotropic action on both atrio-ventricular and intraventricular conduction; 3) effective antiarrhythmic and alpha-blocking action and, inconstantly, 4) the so-called "intrinsic sympathicomimetic action" (I.S.A.), typical of several beta-blocking drugs.