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Research and development improvements in early cancer diagnosis have had a significant positive impact on health. In the treatment and prevention of cancer, early detection is essential. In this context, biomarkers are essential because they offer important information on the state of cells at any particular time. Cells go through unique changes when they shift from a healthy condition to a malignant state, changes that appropriate biomarkers may pick up. Recent advancements have been made to identify and characterize circulating cancer-specific mutations in cell-free circulating DNA derived from tumors and tumor cells. A patient's delay between the time they first detect symptoms and the time they contact a doctor has been noted for many cancer forms. The tumor's location and features significantly impact the presentation of symptoms judged appropriate for early diagnosis. Lack of knowledge of the severity of the symptoms may be one cause for this delay. Our review is largely focused on the ongoing developments of early diagnosis in the study of biomarkers, circulating DNA for diagnosis, the biology of early challenges, early symptoms, liquid biopsies, detectable by imaging, established tumor markers, plasma DNA technologies, gender differences, and artificial intelligence (AI) in diagnosis. This review aims to determine and evaluate Indicators for detecting early cancer, assessing medical conditions, and evaluating potential risks. For Individuals with a heightened likelihood of developing cancer or who have already been diagnosed, early identification is crucial for enhancing prognosis and raising the likelihood of effective treatment.
RESUMO
OBJECTIVE: The purpose of this study is to evaluate the ultimate compressive strength of 50% and 25% Portland cement mixed with Polymer-reinforced zinc oxide eugenol and zinc oxide eugenol cement after 1 hour, 24 hours, and 7 days. MATERIALS AND METHODS: One hundred and eighty samples were selected. The samples were made cylindrical of size 6 × 8 mm and were divided into six groups as follows with each group consisting of 10 samples. Group 1: Polymer-reinforced zinc oxide eugenol with 50% Portland cement (PMZNPC 50%) Group 2: Polymer-reinforced zinc oxide eugenol with 25% Portland cement (PMZNPC 25%) Group 3: Polymer-reinforced zinc oxide eugenol with 0% Portland cement (PMZNPC 0%) Group 4: Zinc oxide eugenol with 50% Portland cement (ZNPC 50%) Group 5: Zinc oxide eugenol with 25% Portland cement (ZNPC 25%) Group 6: Zinc oxide eugenol with 0% Portland cement (ZNPC 0%) These samples were further subdivided based on time interval and were tested at 1 hour, 24 hours and at 7 th day. After each period of time all the specimens were tested by vertical CVR loaded frame with capacity of 5 tones/0473-10kan National Physical laboratory, New Delhi and the results were statistically analyzed using ANOVA and Scheffe test. RESULTS: Polymer-reinforced cement with 50% Portland cement, Zinc oxide with 50% Portland cement, Polymer-reinforced cement with 25% Portland cement and Zinc oxide with 25% Portland cement exhibited higher compressive strength when compared to Zinc oxide with 0% Portland cement and Polymer-reinforced cement with 0% Portland cement, at different periods of time. The difference between these two groups were statistically significant (P < 0.05) and it is suggested that mixture of 50% and 25% Portland cement in Zinc oxide eugenol and Polymer-modified zinc oxide cement can be used as core build up material and permanent filling material. CONCLUSION: It is concluded that 50% and 25% Portland cement in zinc oxide eugenol and polymer-modified zinc oxide eugenol results in higher compressive strength and hence can be used as permanent filling material and core built-up material.
