1.
Bioorg Med Chem Lett
; 11(8): 997-1000, 2001 Apr 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11327608
RESUMO
Several alkenyl derivatives were prepared using allyl penam sulfone as the key intermediate. Isomers of these derivatives having beta configuration at C-6 showed potent activity against CcrA enzyme. A new method was developed to prepare propargyl penam sulfone. The majority of the triazoles prepared by this route exhibited good activity against all three representative enzymes used for the inhibition assay.