RESUMO
Langerhans cell histiocytosis (LCH) is a rare disorder mainly of children, whose pathogenesis is still unknown. Some studies have demonstrated that LCH lesions produce different cytokines abnormally that may be relevant to the pathogenesis of the disease. The purpose of this study was to investigate interleukin-1 beta (IL-1 beta) and prostaglandin E2 (PGE(2)) levels in saliva from children with different clinical subtypes of LCH. We studied 29 children with LCH: seven unifocal (Group I), seven multifocal (Group II), 15 multisystemic (Group III) and 12 healthy volunteers (Group IV). Salivary IL-1 beta and PGE(2) levels were significantly higher in LCH than in normal children. A multi-comparison test showed significantly (P < 0.001) higher levels of both IL-1 beta and PGE(2) in saliva from Group III compared with Groups II and I. A significant correlation (r = 0.05) between IL-1 beta and PGE(2) concentrations in saliva from each group was determined. Our findings demonstrated an association between high concentrations of salivary IL-1 beta and PGE(2) and advanced stages of the disease. This allows us to suggest that the abnormal amount of these factors in saliva may serve as a risk marker for disease progression.
Assuntos
Dinoprostona/metabolismo , Histiocitose de Células de Langerhans/metabolismo , Interleucina-1beta/metabolismo , Saliva/metabolismo , Análise de Variância , Biomarcadores/metabolismo , Estudos de Casos e Controles , Pré-Escolar , Feminino , Histiocitose de Células de Langerhans/classificação , Humanos , Masculino , Valores de Referência , Índice de Gravidade de DoençaRESUMO
Problemas gingivales y periodontales en niños y adolescentes, Virginia F. de Preliasco y Hugo Romanelli. Criterios quirúrgicos en odontopediatría, José Luis Ferrería
Assuntos
Odontologia Preventiva , Doenças Periodontais/cirurgia , Criança , Cirurgia Bucal/métodosRESUMO
Programa de educación continua odontologica no convencional
Assuntos
Odontopediatria , ODONTOLOGIA INTEGRAL NINOS , Periodontia , Cirurgia Bucal , Odontopediatria , OdontopediatriaRESUMO
Programa de educación continua odontologica no convencional. Odontologia integral para niños II
Assuntos
Odontopediatria , ODONTOLOGIA INTEGRAL NINOS , Emergências , Traumatismos Dentários , Odontopediatria , OdontopediatriaRESUMO
Programa de educación continua odontologica no convencional
Assuntos
ATENCION INTEGRAL NINOS , Dentística Operatória , Reabilitação Bucal , Odontopediatria , OdontopediatriaRESUMO
Programa de educación continua odontologica no convencional
Assuntos
ATENCION INTEGRAL NINOS , Saúde Bucal , Psicologia , Odontopediatria , OdontopediatriaRESUMO
Programa de educación continua odontologica no convencional. Odontologia integral para niños II
Assuntos
OdontopediatriaRESUMO
Prevención de traumatismos. Tratamiento de dientes traumatizados
Assuntos
Traumatismos Dentários/prevenção & controle , Traumatismos Dentários/terapia , Traumatismos DentáriosRESUMO
Prevención de traumatismos. Tratamiento de dientes traumatizados
