[Preleukemia]. / Preleukoze.

The six cases of Preleukemia (or Preleukemic States) are described. The peripheral blood was characterised with Pancythopoenia in 5 and bicytopoenia in 1 patient. Morphological alterations of Erythrocytes were present in all cases. The Bone Marrow was hypercellular in 3 and hypocellular in 3 patients. Erythropoiesis was megaloblastic or partly megaloblastic in 5 cases, with "ring" sideroblasts present in all cases. The percentage of Leukemic blast cells was as follow: 0, 5, 6, 10, 30 and 33. The duration of the preleukemic phase varied from 3-53 months. With the manifestations of overt Acute Nonlymphatic Leukemia the agressive therapy was applied. The results were poor in 5 patients (the survival 1, 5-4 m.). Only one survived more than 60 months and is still in full remission.

[Treatment of acute leukoses at the Internal Clinic of the Dr. Z. Kucic Hospital in Rjeka]. / Terapija akutnih leukoza na internoj klinici bolnice "Dr. Z. Kucic u Rijeci

The offects of treatment achieved in 35 patients with Acute Leukemia have been presented. In the group of 10 patients with Acute Lymphocytic Leukemia remission have been obtained in 9 patients with the mean survival of 13,7 months. In the group of 25 patients with Acute Nonlymphocytic Leukemia remissions have been obtained in 16 patients with the mean survival of 9, 6 months.

[Acute erythremic myelosis as a terminal phase of polycythemia rubra vera]. / Akutna eritremicna mijeloza kao terminalna faza policitemije rubre vere

A male, 66, developed Acute Erythremic Myelosis in the course of Polycythemia Vera. The time of onset of Polycythemia Vera could not be determined, his first symptoms being vascular complications. He received treatment with Phlebotomies and Myleran. Five years later he became ill with malaise, fever, splenomegaly; in the peripheral blood profound pancytopoenia with immature, bizzare erythro-and megaloblasts have been found. Bone marrow was full of atypical megaloblasts, some of them having two or more nuclei. The number of mitoses was increased. Chromosomal abnormalities consisted of ane-uploid cells, chromatid breakes and translocations (G to A-1). The therapy with B12, Cytosin-Arabinoside, Oncovin and Blood transfusions was unsuccessful. He died 21 days after being admitted to the Hospital.