RESUMO
BACKGROUND: The neuropathological consequences of Gamma Knife radiosurgery (GK) on hypothalamic hamartoma (HH) are unknown. OBJECTIVE: In a cohort of patients undergoing surgery for treatment-resistant epilepsy, we compared surgically resected HH tissue from patients without (group I; n = 19) and with (group II; n = 10) a history of GK (median dose 16 Gy to the 50% isodose margin). METHODS: Techniques included thick-section stereology for total nucleated and total neuron cell counts, and thin-section immunohistochemistry. Normal human hypothalamus derived from age-matched autopsy material was used as control tissue for CD68 immunohistochemistry. Qualitative scoring of tissue sections was performed by a neuropathologist who was blind to the GK treatment history. RESULTS: GK is associated with decreased total cell density (p < 0.02). A dose-dependent association of GK with decreased total neuron density approached significance (p = 0.06). Group II HH tissue had significantly more (1) reactive gliosis, (2) thickened capillary endothelium and (3) microglial activation. Degenerative features, including karyorrhexis and pyknotic nuclei, were infrequent in group II and absent in group I HH tissue. CONCLUSIONS: Nonnecrotizing doses of GK radiosurgery decrease cell density in human HH tissue. Cell loss resulting from GK may contribute to decreased excitation in the neuronal networks responsible for seizure onset in HH tissue.
Assuntos
Hamartoma/patologia , Doenças Hipotalâmicas/patologia , Radiocirurgia , Adolescente , Anticonvulsivantes/uso terapêutico , Contagem de Células , Morte Celular , Núcleo Celular/ultraestrutura , Criança , Pré-Escolar , Terapia Combinada , Endotélio Vascular/patologia , Epilepsia/tratamento farmacológico , Epilepsia/etiologia , Epilepsia/cirurgia , Feminino , Gliose/etiologia , Gliose/patologia , Hamartoma/complicações , Hamartoma/cirurgia , Humanos , Doenças Hipotalâmicas/complicações , Doenças Hipotalâmicas/cirurgia , Lactente , Masculino , Microglia/patologia , Neurônios/patologia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/patologia , Estudos Retrospectivos , Método Simples-Cego , Adulto JovemRESUMO
OBJECT: This study aimed at identifying outcomes with respect to seizures, morbidity, and mortality in adult patients undergoing resective or Gamma Knife surgery (GKS) to treat intractable epilepsy associated with hypothalamic hamartoma (HH). METHODS: Adult patients undergoing surgical treatment for HH-related epilepsy were prospectively monitored at a single center for complications and seizure outcome by using a proprietary database. Preintervention and postintervention data for patients 18 years of age and older, and with at least 1 year of follow-up, were analyzed, with specific attention to seizure control, complications, hormonal status, and death. RESULTS: Forty adult patients were found in the database (21 were women). The median HH volume was 0.54 cm(3). In 70% of patients, it was located inside the third ventricle, attached unilaterally and vertically to the hypothalamus (Delalande Type II). Most patients (26) underwent an endoscopic resection, 10 patients had a transcallosal or other type of open (pterional or orbitozygomatic) resection, and 4 patients chose GKS. Twenty-nine percent became seizure free in the long term, and overall a majority of patients (55%) reported at least > 90% seizure improvement. Only 3 patients were ultimately able to discontinue anticonvulsants, whereas most patients were taking an average of 2 antiepileptic drugs pre- and postoperatively. The only factor significantly correlated with seizure-free outcome was the absence of mental retardation. The HH volume, HH type, and amount of resection or disconnection were not correlated to seizure freedom. A total of 4 patients (10%) died, 2 immediately after surgery and 2 later. All of them had undergone a resection, as opposed to GKS, and still had seizures. Postoperatively, persistent neurological deficits were seen in 1 patient; 34% of patients had mild hormonal problems; and 59% experienced weight gain of at least 6.8 kg (average gain 12.7 kg). CONCLUSIONS: Surgical or GKS procedures in adults with HH provided seizure freedom in one-third of patients. The only significant favorable prognostic factor was the absence of mental retardation. The overall mortality rate was high, at 10%. Other important morbidities were persistent hormonal disturbances and weight gain.
Assuntos
Craniotomia , Endoscopia , Epilepsias Parciais/cirurgia , Hamartoma/cirurgia , Doenças Hipotalâmicas/cirurgia , Radiocirurgia , Adolescente , Adulto , Eletroencefalografia , Epilepsias Parciais/diagnóstico , Epilepsias Parciais/mortalidade , Feminino , Hamartoma/diagnóstico , Hamartoma/mortalidade , Mortalidade Hospitalar , Humanos , Doenças Hipotalâmicas/diagnóstico , Doenças Hipotalâmicas/mortalidade , Interpretação de Imagem Assistida por Computador , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/mortalidade , Estudos Prospectivos , Processamento de Sinais Assistido por Computador , Taxa de Sobrevida , Terceiro Ventrículo/cirurgia , Resultado do Tratamento , Adulto JovemRESUMO
Hypothalamic hamartomas present with isolated fits of ictal laughter (gelastic epilepsy) or a combination of gelastic and other types of seizures. Many of these patients also suffer from cognitive decline, neuropsychiatric comorbidities and precocious puberty. Although there is a large body of anecdotal evidence about hypothalamic hamartomas and gelastic seizures, many questions still remain to be answered. For instance, which specific hypothalamic regions are most affected by the location of hamartomas causing laughing versus other types of seizures? Does the neuroanatomical localization of the lesions differ in cases with only gelastic seizures or a combination of gelastic and other types of seizures? Does the location of the lesions correlate with the presence of precocious puberty, and does the type of lesion influence the severity or the type of seizures? In a retrospective review of clinical and structural neuroimaging data from 100 cases of gelastic epilepsy and hypothalamic hamartoma, we aimed to address these questions by analysing the clinical presentation and the neuroanatomical features of the hypothalamic lesions in these patients. Our findings suggest that in all 100 cases, lesions were centred at the level of the mammillary bodies in the posterior hypothalamus. Compared with the patients with pure gelastic seizures (n = 32), those with gelastic and other types of seizures (n = 68) had significantly longer duration of epilepsy (P < 0.001), whereas age of seizure onset, the volume of lesions and the proximity to the mammillary bodies were not different between the two groups. In contrast, patients with cognitive or developmental impairment and those with precocious puberty had significantly larger lesions involving the anterior and posterior hypothalamus.
Assuntos
Epilepsias Parciais/patologia , Hamartoma/patologia , Doenças Hipotalâmicas/patologia , Hipotálamo/patologia , Riso , Adolescente , Criança , Pré-Escolar , Epilepsias Parciais/etiologia , Feminino , Hamartoma/complicações , Humanos , Doenças Hipotalâmicas/complicações , Imageamento por Ressonância Magnética , Masculino , Corpos Mamilares/patologiaRESUMO
PURPOSE: Hypothalamic hamartomas (HHs) are a malformation of the ventral hypothalamus and tuber cinereum, associated with gelastic seizures and epilepsy. We sought to determine the spectrum of electroencephalography (EEG) abnormalities in a large cohort of HH patients. METHODS: Data was collected for HH patients undergoing evaluation between 2003 and 2007. Data included seizure history, prior treatment, and results of diagnostic studies. After informed consent, data were entered into a database. KEY FINDINGS: We reviewed 133 HH patients. Mean age at time of data analysis was 15.7 years (59.4% male). Most patients had gelastic (77%) and/or complex partial seizures (58%). Records for 102 EEG studies on 73 patients were reviewed. Interictal epileptiform abnormalities were seen in 77%, localizing predominately to the temporal and frontal regions. Records for 104 video-EEG (VEEG) studies on 65 patients were reviewed. Of 584 gelastic seizures (GS) captured, no ictal EEG change was noted in 438 (75%). Of GS with localizing features, 89% suggested onset from the temporal and/or frontal regions. There were 160 complex partial seizures (CPS). For those with localizing features, 100% localized to the temporal and/or frontal head regions. EEG and VEEG findings correlated with the side of HH attachment. VEEG did not influence outcome. SIGNIFICANCE: EEG features in HH patients are diverse. The majority of gelastic seizures fail to demonstrate change in the EEG. The lack of EEG changes with many clinical seizures, and the false localization seen in those events with an ictal change suggest the utility of EEG is limited in the evaluation of these patients.
Assuntos
Eletroencefalografia , Epilepsia/diagnóstico , Epilepsia/fisiopatologia , Gravação em Vídeo , Adolescente , Adulto , Criança , Pré-Escolar , Estudos de Coortes , Eletroencefalografia/métodos , Epilepsia/complicações , Feminino , Hamartoma/complicações , Hamartoma/diagnóstico , Hamartoma/fisiopatologia , Humanos , Doenças Hipotalâmicas/complicações , Doenças Hipotalâmicas/diagnóstico , Doenças Hipotalâmicas/fisiopatologia , Lactente , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Estudos Retrospectivos , Convulsões/complicações , Convulsões/diagnóstico , Convulsões/fisiopatologia , Gravação em Vídeo/métodos , Adulto JovemRESUMO
Hypothalamic hamartomas (HHs) are associated with treatment-resistant epilepsy. Many patients also experience severe and sometimes disabling psychiatric problems. The most common behavioral symptoms consist of paroxysms of uncontrolled anger related to poor frustration tolerance. These can include violence, resulting in disrupted family or school relationships, and legal consequences including incarceration. In a large cohort of patients undergoing surgical resection of HHs for refractory epilepsy, 88% of families described an improvement in overall behavioral functioning [1]. Here, we describe four patients (three males, mean age=11.9 years) who underwent surgical resection of HHs largely for behavioral indications. Three patients had relatively well controlled seizures, and one had no history of epilepsy. All patients had striking improvement in their psychiatric comorbidity. HH resection can result in significant improvement in behavioral functioning, even in patients with relatively infrequent seizures. Further investigation under approved human research protocols is warranted.
Assuntos
Encéfalo/cirurgia , Epilepsia/cirurgia , Transtornos Mentais/cirurgia , Adolescente , Criança , Epilepsia/etiologia , Feminino , Hamartoma/complicações , Hamartoma/cirurgia , Humanos , Doenças Hipotalâmicas/complicações , Doenças Hipotalâmicas/cirurgia , Masculino , Transtornos Mentais/etiologia , Resultado do TratamentoRESUMO
PURPOSE: This study aims to examine the outcomes of ten patients after orbitozygomatic (OZ) pterional surgery in cases of refractory epilepsy caused by hypothalamic hamartomas (HH). METHODS: Ten patients with HH and treatment-resistant epilepsy (mean age 18.3 years, range 0.7 to 42.7) underwent HH resection with an OZ approach (n = 8) or an OZ approach combined with a transventricular endoscopic approach (n = 2). Follow-up for the patients ranged from 0.5 to 6.2 years (mean 3.1). Outcomes were prospectively monitored with the use of a proprietary database. RESULTS: Four patients (40%) are seizure-free, and four (40%) have had greater than 50% reduction in seizures. One patient had no significant change in seizure frequency, and one patient died unexpectedly 2.8 years after surgery. Six patients had total or near-total HH resection (98-100% of HH lesion volume). Of these, four of six (66%) were seizure-free, and two had at least greater than 50% reduction in seizures. Residual complications include diabetes insipidus (n = 1), poikilothermia (n = 1), visual field deficit (n = 1), and hemiparesis (n = 1). Eight families (80%) reported improved quality of life. CONCLUSIONS: Patients with treatment-resistant epilepsy and tumors with an inferior or horizontal plane of attachment to the hypothalamus should continue to be approached from below. Those with both intrahypothalamic and parahypothalamic components may require approaches from above and below, either simultaneously or staged. For appropriately selected patients, the success of controlling seizures with an OZ is comparable to results utilizing transcallosal or transventricular approaches. The likelihood of controlling seizures appears to correlate with extent of resection.
Assuntos
Epilepsia/cirurgia , Procedimentos Neurocirúrgicos/métodos , Adolescente , Adulto , Criança , Pré-Escolar , Epilepsia/etiologia , Feminino , Hamartoma/complicações , Hamartoma/cirurgia , Humanos , Doenças Hipotalâmicas/complicações , Doenças Hipotalâmicas/cirurgia , Masculino , Seleção de Pacientes , Resultado do TratamentoRESUMO
BACKGROUND/AIMS: Hypothalamic hamartomas are the most common identifiable cause of central precocious puberty (CPP). Hamartoma characteristics proposed to be associated with CPP include specific anatomic features and expression of molecules such as gonadotropin-releasing hormone (GnRH), transforming growth factor alpha (TGFalpha), and GRM1A, which encodes the type 1 metabotropic glutamate receptor alpha isoform. We sought to determine whether hamartomas that cause CPP could be distinguished by anatomic features, expression of these molecules, or expression of KISS1, whose products signal through the receptor GPR54 to stimulate GnRH release. METHODS: Clinical records and radiologic images were reviewed for 18 patients who underwent hamartoma resection for intractable seizures; 7 had precocious puberty. Resected tissue was examined for expression of GnRH, GnRH receptor (GnRHR), TGFalpha, KISS1, GPR54, and GRM1A. RESULTS: Hypothalamic hamartomas associated with CPP were more likely to contact the infundibulum or tuber cinereum and were larger than hamartomas not associated with CPP. GnRH, TGFalpha, and GnRHR were expressed by all hamartomas studied. Expression of KISS1, GPR54, and GRM1A did not differ significantly between hamartomas associated and not associated with CPP. CONCLUSION: Anatomic features rather than expression patterns of candidate molecules distinguish hypothalamic hamartomas that are associated with CPP from those that are not.
Assuntos
Hormônio Liberador de Gonadotropina/biossíntese , Hamartoma/complicações , Doenças Hipotalâmicas/complicações , Puberdade Precoce/etiologia , Fator de Crescimento Transformador alfa/biossíntese , Proteínas Supressoras de Tumor/biossíntese , Adolescente , Criança , Pré-Escolar , Feminino , Expressão Gênica , Hamartoma/diagnóstico por imagem , Hamartoma/metabolismo , Hamartoma/patologia , Hamartoma/cirurgia , Humanos , Doenças Hipotalâmicas/diagnóstico por imagem , Doenças Hipotalâmicas/patologia , Lactente , Kisspeptinas , Masculino , Puberdade Precoce/patologia , Radiografia , Receptores LHRH/biossíntese , Convulsões/etiologia , Convulsões/cirurgiaRESUMO
OBJECTIVE: The goal of the work described here was to examine the relationship between intellectual test performance in patients with hypothalamic hamartoma (HH) with refractory epilepsy and their seizure histories, as well as the size and neuroradiographic anatomical features of the HH. It was predicted that the level of estimated intelligence and the pattern of intellectual test performance would significantly correlate with the size of the HH and neuroanatomical features. METHOD: In this cross-sectional design study, 49 patients with HH between the ages of 5 and 55 years were classified by age at time of examination, as well as pattern of performance on the Wechsler intelligence scales. All patients were included in data analysis irrespective of their ability to participate in psychometric testing. Patients with a prior history of neurosurgical treatment were excluded. RESULTS: For those patients functionally capable of participating in cognitive testing (n=42), a summary index score, which estimated level of intellectual function (composed of the Vocabulary, Block Design, and Coding subtests of the Wechsler intelligence scales), was significantly correlated only with number of antiepileptic drugs (AEDs) the patient was taking at the time of evaluation (r=-0.66, n=38, P=0.05). In contrast, a categorization method addressing the pattern of intellectual test performance (including those patients who were not functionally capable of participating in cognitive testing, n=49) was significantly correlated with number of AEDs (r=+0.35, n=48, P=0.01), size of HH (r=+0.38, n=49, P=0.01), presence of precocious puberty (PP: r=+0.41, n=49, P=0.01), and anatomical classification of HH (r=+0.39, n=49, P=0.01). CONCLUSIONS: The findings confirm the wide range of cognitive functioning in the population of patients with HH and refractory epilepsy, and suggest that multiple variables are correlated with intellectual test performance in patients with HH with refractory epilepsy. Although the present cross-sectional design study does not answer the question of whether or not epilepsy severity produces lower intelligence in this patient population, number of AEDs and neuroanatomical features of the HH lesion are identified as being significantly related to cognitive performance in this patient sample.
Assuntos
Epilepsia/fisiopatologia , Hamartoma/fisiopatologia , Doenças Hipotalâmicas/fisiopatologia , Inteligência/fisiologia , Adolescente , Adulto , Anticonvulsivantes/uso terapêutico , Criança , Pré-Escolar , Cognição/efeitos dos fármacos , Epilepsia/tratamento farmacológico , Feminino , Humanos , Inteligência/efeitos dos fármacos , Testes de Inteligência , Masculino , Pessoa de Meia-Idade , Testes NeuropsicológicosRESUMO
Hypothalamic hamartomas (HHs) are rare developmental tumors that cause seizures or pituitary axis dysfunction, usually beginning in childhood. We analyzed HH tissue from 57 patients whose tumors were resected through recently developed transcallosal interforniceal and transventricular endoscopic surgical approaches. All cases were composed of abnormally distributed but cytologically normal neurons and glia, including fibrillary astrocytes and oligodendrocytes. Neuronal elements predominated in most cases, but a relative increase in astrocytic elements was seen with increasing age. All had various sized nodular foci of neurons as well as areas of diffusely distributed neurons with interspersed glial cells. Smaller neurons predominated, and most cases had only a few interspersed large ganglion cells. Immunohistochemistry demonstrated extensive production of synapse-associated proteins. Immunohistochemistry for phosphorylated and nonphosphorylated neurofilament and alpha-internexin demonstrated staining patterns consistent with mature neurons. In contrast to cortical dysplasia, atypical large ganglion-like balloon cells were almost never seen. In summary, although their number and distribution vary, mature smaller neurons were the most prominent and most consistent histologic feature of HH. Nodules of these small neurons were a universal feature of the microarchitecture of HH lesions associated with epilepsy. Characterization of these neurons may aid in understanding the mechanism of seizure development in HH.
Assuntos
Hamartoma/patologia , Doenças Hipotalâmicas/patologia , Hipotálamo/anormalidades , Hipotálamo/patologia , Adolescente , Adulto , Astrócitos/citologia , Astrócitos/metabolismo , Biomarcadores/metabolismo , Criança , Pré-Escolar , Epilepsia/etiologia , Epilepsia/patologia , Epilepsia/fisiopatologia , Feminino , Hamartoma/metabolismo , Hamartoma/fisiopatologia , Humanos , Doenças Hipotalâmicas/metabolismo , Doenças Hipotalâmicas/fisiopatologia , Hipotálamo/fisiopatologia , Imuno-Histoquímica , Lactente , Masculino , Pessoa de Meia-Idade , Proteínas do Tecido Nervoso/metabolismo , Neurônios/citologia , Neurônios/metabolismo , Neurópilo/citologia , Neurópilo/metabolismoRESUMO
PURPOSE: A small number of patients with hypothalamic hamartoma (HH) present with infantile spasms (IS) as an initial or early seizure type. We describe the clinical features of IS associated with HH. METHODS: Our series of patients with HH and epilepsy was reviewed to identify cases with a history of IS. The clinical features and neuroradiological findings in this study group were compared to a control group of patients with HH and refractory epilepsy, but without a history of IS. RESULTS: We identified six patients with HH and a history of IS in this series (n = 122, 4.9%). Five of the six are male. Four of the six patients (67%) developed IS as their first seizure type. The mean age for onset of IS was 6.2 months (range 4-9 months). Results of electroencephalographic (EEG) study at the time of IS diagnosis showed hypsarrhythmia in two (33%). Five patients were treated with adrenocorticotropic hormone (ACTH), and four of the five (80%) responded with control of IS. However, these patients developed other seizure types, and were ultimately refractory to medical management. Aside from the IS, no significant differences in clinical and imaging features were determined between the study group and the control group. CONCLUSIONS: HH should be included in the differential diagnosis for infants presenting with IS. These patients may have hypsarrhythmia on initial EEG, and may respond to ACTH treatment with improvement of IS. However, all became refractory with other seizure types, more commonly seen in HH patients. Focal pathologies associated with IS may be subcortical, as well as cortical, in nature. We have not identified any predictive features for the occurrence of IS in the HH population.
Assuntos
Hamartoma/diagnóstico , Neoplasias Hipotalâmicas/diagnóstico , Espasmos Infantis/diagnóstico , Adolescente , Hormônio Adrenocorticotrópico/uso terapêutico , Adulto , Idade de Início , Criança , Pré-Escolar , Hormônio Liberador da Corticotropina/fisiologia , Diagnóstico Diferencial , Eletroencefalografia/estatística & dados numéricos , Epilepsia/diagnóstico , Feminino , Hamartoma/epidemiologia , Hormônios/uso terapêutico , Humanos , Neoplasias Hipotalâmicas/epidemiologia , Incidência , Lactente , Imageamento por Ressonância Magnética , Masculino , Modelos Neurológicos , Fatores Sexuais , Espasmos Infantis/tratamento farmacológico , Espasmos Infantis/fisiopatologia , Resultado do TratamentoRESUMO
PURPOSE: To present the results of transcallosal surgical resection of hypothalamic hamartoma (HH) in 26 patients with refractory epilepsy in a prospective outcome study. METHODS: Patients with refractory epilepsy symptomatic to HH were referred for surgical resection of their HH (mean age, 10.0 years; range, 2.1-24.2 years). A transcallosal, interforniceal approach was used to remove and/or disconnect the hamartoma. Volumetry was obtained on pre- and postoperative brain MRI scans to determine percentage of resection. Outcome assessment included determination of postoperative seizure frequencies in comparison to baseline and the incidence of postoperative complications. Postoperative changes in cognitive and behavioral functioning, in comparison to baseline, were elicited by parental report. RESULTS: The average postoperative follow-up interval was 20.3 months (range, 13-28 months). Fourteen (54%) patients were completely seizure free, and nine (35%) had at least a 90% improvement in total seizure frequency. Parents reported postoperative improvement in behavior in 23 (88%) patients and in cognition in 17 (65%) patients. Transient postoperative memory disturbance was seen in 15 (58%) patients, but persisted in only two (8%). Two (8%) patients had persisting endocrine disturbance requiring hormone replacement therapy (diabetes insipidus and hypothyroidism in one each). With univariate analysis, the likelihood of a seizure-free outcome correlated with younger age, shorter lifetime duration of epilepsy, smaller preoperative HH volume, and 100% HH resection. CONCLUSIONS: Refractory epilepsy associated with HH can be safely and effectively treated with surgical resection by a transcallosal, interforniceal approach. Short-term memory deficits appear to be transient for most patients, and family perception of the impact of surgery on cognitive and behavioral domains is favorable. Complete resection yields the best result.
Assuntos
Corpo Caloso/cirurgia , Epilepsia/cirurgia , Hamartoma/cirurgia , Doenças Hipotalâmicas/cirurgia , Procedimentos Neurocirúrgicos/métodos , Adolescente , Adulto , Fatores Etários , Atitude Frente a Saúde , Criança , Pré-Escolar , Corpo Caloso/patologia , Epilepsia/patologia , Família/psicologia , Feminino , Seguimentos , Hamartoma/patologia , Humanos , Doenças Hipotalâmicas/patologia , Hipotálamo/patologia , Hipotálamo/cirurgia , Imageamento por Ressonância Magnética , Masculino , Transtornos da Memória/epidemiologia , Microcirurgia/métodos , Técnicas Estereotáxicas , Análise de Sobrevida , Resultado do TratamentoRESUMO
The authors report the case of a 12-year-old girl with Pallister-Hall syndrome, long-standing refractory, symptomatic epilepsy, mental retardation, and panhypopituitarism in whom two rare, deep midline lesions were detected. She underwent successful transsphenoidal resection of the Rathke cleft cyst and transcallosal resection of the hypothalamic hamartoma within a 4-day period without complications. Neuropathological studies confirmed the neuroimaging diagnoses for the two lesions. The patient has been seizure free for 6 months postoperatively.
Assuntos
Cistos do Sistema Nervoso Central/cirurgia , Hamartoma/cirurgia , Neoplasias Hipotalâmicas/cirurgia , Cistos do Sistema Nervoso Central/complicações , Cistos do Sistema Nervoso Central/patologia , Criança , Feminino , Hamartoma/complicações , Hamartoma/patologia , Humanos , Neoplasias Hipotalâmicas/complicações , Neoplasias Hipotalâmicas/patologia , Convulsões/etiologia , Resultado do TratamentoRESUMO
BACKGROUND AND PURPOSE: Commercially available software programs for the conversion of dynamic CT perfusion (CTP) source data into cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time (MTT) maps require operators to subjectively define parameters that are used in subsequent postprocessing calculations. Our purpose was to define the variability of CBV, CBF, and MTT values derived from CTP maps generated from the same source data postprocessed by three different CT technologists (CTTs). METHODS: Raw data derived from dynamic CTP examinations performed in 20 subjects were postprocessed seven times by three experienced CTTs. Parenchymal regions of interest derived from each map (CBV, CBF, and MTT) were compared. The CBF maps generated by each technologist were also qualitatively assessed. Decisions made by each analyzer during postprocessing were assessed. RESULTS: The intraclass correlation coefficients were 0.73 (95% CI, 0.64-0.81), 0.87 (0.83-0.91) and 0.89 (0.85-0.93), for the CBV, CBF, and MTT parenchymal regions of interest, respectively. All individual correlation coefficients between data sets were significant to a P value <.05. Measurement error, made solely on the basis of different technologists postprocessing the same source data and expressed as the coefficients of variation, were 31%, 30%, and 14% for CBV, CBF, and MTT, respectively. The selection of the arterial input function (AIF) region of interest, venous function region of interest, and preenhancement interval were very reproducible. The technologists differed significantly with respect to the selection of the postenhancement image (PoEI) (P <.01). A retrospective review of the individual CBF maps indicated that variance in the PoEI selection accounted for much of the variation in the qualitative appearance of the CBF maps generated by different technologists. The PoEI was selected to demarcate the baseline of the AIF time-attenuation curve. It is likely that this method of PoEI selection significantly contributed to intra- and interanalyzer variability. CONCLUSION: There is a high degree of correlation between parenchymal regions of interest derived from CBV, CBF, and MTT maps generated from the same dynamic CTP source data postprocessed by different operators. The level of agreement, however, may not be sufficient to incorporate quantitative values into clinical decision making. Quantitative differences between parenchymal regions of interest were not infrequently manifest as significant differences in the qualitative appearance of the CBF maps. It is likely that, with optimization of postprocessing parameter selection, the degree of variability may be substantially reduced.
Assuntos
Processamento de Imagem Assistida por Computador , Perfusão , Tomografia Computadorizada por Raios X , Arizona , Volume Sanguíneo/fisiologia , Circulação Cerebrovascular/fisiologia , Transtornos Cerebrovasculares/diagnóstico por imagem , Transtornos Cerebrovasculares/fisiopatologia , Tomada de Decisões , Humanos , Variações Dependentes do Observador , Radiologia , Reprodutibilidade dos Testes , Estatística como Assunto , Fatores de TempoRESUMO
We evaluated 13 children with cerebral palsy who had birthweights under 1085 g. A magnetic resonance image (MRI) of the head was obtained, the findings were compared, and the neonatal records were reviewed. The individual children were classified as to the type of cerebral palsy. On MRI, all had severe injury to the inferior cerebellar hemispheres, mostly symmetric, and in some there was injury to the inferior vermis. The average birthweight was 668 g, and the gestational ages were 24 to 27 weeks. No other outstanding prenatal or postnatal problems were identified. The children had different types of severe cerebral palsy, with only 3 being able to walk. Almost all were mentally retarded and microcephalic. All had visual problems. This report defines a previously underappreciated injury to the cerebellum in extremely premature infants. Further clinical, laboratory, and pathologic studies are needed to better define the underlying mechanisms.