General anaesthesia in a patient affected by Brugada syndrome.

This case report describes an asymptomatic patient with positive familiar anamnesis of Brugada syndrome (BrS) who elected to undergo surgery. The anaesthesiological technique using propofol, fentanyl, atracurium, air/oxygen did not induce any electrocardiographic alteration during the operation; the intraoperation use of a biphasic defibrillator was critical here. The cerebral state index and adhesive plaques connected with a biphasic defibrillator having PM capabilities allowed us to monitor the operation and continually assess the patient's cardiac stability. Afterwards, the patient was transferred to the intensive care unit and was monitored for 24 hours. This anesthesiological technique was performed in place of ARL, which the patient refused.

Density and composition of trabecular and cortical bone in perinatally irradiated beagles with chronic renal failure.

Bone density and composition were studied in trabecular and cortical bone from control 2 and 4 year old beagles and those which had various degrees of renal failure as a result of perinatal irradiation. Changes in the two types of bone were qualitatively similar but consistently greater in trabecular bone. In a group identified as markedly uremic, the decrease (P less than 0.025) from control levels in specific gravity was about 4 times greater in trabecular than in cortical samples. The decrease (P less than 0.025) in grams of ash/ml was 9% in trabecular bone and 2% in cortical bone. These changes were associated with an increase (P less than 0.001) in water content and, on a percent by volume basis, approximately equal decreases in ash (P less than 0.025) and combustible matter (P less than 0.025). In a mildly uremic group there were similar trends in mean values but the only significant difference was an increase (P less than 0.001) in trabecular bone water.