1.
Mem Inst Oswaldo Cruz
; 86(4): 501-3, 1991.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1842453
2.
Rev Bras Pesqui Med Biol
; 11(4-5): 229-35, 1978 Oct.
Artigo
em Português
| MEDLINE
| ID: mdl-725135
RESUMO
Proteins from plasmatic membrane of ascites and solid 20-methylcholantrene induced tumours cells in inbred mice and rats were obtained by isolation of vesicles of tumor cell membranes produced in glycerol solution. The tumour cells were not broken. In a syngeneic system the inoculation of the prepared protein with adjuvant resulted in protection of 50 to 100% of animals against challenge with a syngeneic tumour cells. The same results were obtained with Ehrlich ascites tumour. The lymphocyte cytotoxicity and blastic transformation of lymphocytes in immunized animals suggested a cellular cytotoxic immunity mediated by tumour specific antigen or perhaps by fetal antigen.