[The clinical and pharmacokinetic features of lymphotropic therapy in patients with new-onset pulmonary tuberculosis].

Regional lymphotropic therapy used in complex treatment of patients with new-onset pulmonary tuberculosis enhances its efficiency. It is well tolerated by patients and easy-to-use. The pharmacokinetic feature of isoniazid during its lymphotropic administration is its shorter elimination half-life, decreased total clearance, and a larger area under the pharmacokinetic curve.

[Measurement of the chemiluminescence of the urine and blood serum during the adverse effects of drugs on patients with tuberculosis]. / Khemiliuminometriia mochi i syvorotki krovi pri pobochnom deistvii lekarstv u bol'nykh tuberkulezom.

Materials on testing of urine and blood serum by chemiluminometry (CLM) for diagnosis of adverse reactions to drugs in patients with tuberculosis are presented. Urine and blood serum from 94 patients with pulmonary tuberculosis were tested. The group included 59 patients with allergic, toxico-allergic and toxic reactions to the antituberculous drugs used in their treatment, 17 patients with satisfactory tolerance of the treatment and 18 patients subjected to the tests prior to their treatment. The diagnostic value of the urine tests was rather high (84.7 per cent) and not inferior to that of the blood serum tests (86.4 per cent). The simultaneous testing of both the media increased the frequency of detecting the sensitizing drug. The procedure is simple, not harmful for the patients and provides rapid results (20-30 minutes) and objective estimation. It may be recommended for the use in medical institutions.