RESUMO
Coenzyme Q10 was administered under placebo controlled blinded crossover conditions to six subjects suffering from type 3 3-methylglutaconic aciduria ('optic atrophy plus'), following a report of benefit. Despite attainment of high plasma levels of coenzyme Q10, no clinical benefit was observed and there was no diminution of urinary excretion of 3-methylglutaconic acid.
Assuntos
Glutaratos/urina , Ubiquinona/análogos & derivados , Administração Oral , Adolescente , Adulto , Criança , Coenzimas , Estudos Cross-Over , Feminino , Humanos , Masculino , Transtornos dos Movimentos/complicações , Doenças Neuromusculares/complicações , Atrofia Óptica/complicações , Método Simples-Cego , Falha de Tratamento , Ubiquinona/sangue , Ubiquinona/uso terapêutico , Acuidade Visual/efeitos dos fármacosRESUMO
We describe 19 cases of a familial syndrome consisting of infantile optic atrophy and an early movement disorder in which chorea predominated. About one-half the patients developed spastic paraparesis during the second decade of life. Ataxia and cognitive deficits were common, usually of mild degree. Seventeen of the patients were females. Sixteen had similarly affected siblings, but none had affected parents. All but one belonged to the Iraqi Jewish community in Israel, giving a minimal prevalence rate in this ethnic group of about 1:10,000.
Assuntos
Anormalidades do Olho , Transtornos dos Movimentos/genética , Paraplegia/genética , Espasmo/genética , Adolescente , Adulto , Atrofia , Criança , Olho/patologia , Feminino , Humanos , Masculino , SíndromeRESUMO
Orbital emphysema is usually described in association with fractures of the paranasal sinuses involving the orbit. We describe a rare form of orbital emphysema caused by high-pressure subconjunctival air injection from an air tube used in a garage, without apparent damage to the orbital walls.
Assuntos
Traumatismos Oculares/complicações , Doenças Orbitárias/etiologia , Ferimentos não Penetrantes/complicações , Fenômenos Biomecânicos , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Orbitárias/diagnóstico por imagem , Doenças Orbitárias/cirurgia , Radiografia , TomografiaRESUMO
A study of the postoperative evolution of 70 eyes subjected to trabeculectomy over a 3-year period is reported. This is the operation of choice in our department in cases of chronic open-angle glaucoma and chronic angle-closure glaucoma. The study showed that in 35.7% of the operated eyes the intraocular pressure was increased on the second postoperative day and became normal within a week. This raised intraocular pressure did not influence the final result of the operation.
