Francisella tularensis Infection Causing Parinaud Oculoglandular Syndrome.

BACKGROUND Parinaud oculoglandular syndrome is a unilateral granulomatous palpebral conjunctivitis associated with preauricular, submandibular, and cervical lymphadenopathies. Several infectious diseases can cause Parinaud oculoglandular syndrome, usually with a conjunctival entry. The most common underlying pathology is cat scratch disease, followed by the oculoglandular form of tularemia. Diagnosis is usually a serious challenge as these infections are themselves rare. On the other hand, Parinaud oculoglandular syndrome may be a rare manifestation of more common disorders (eg, tuberculosis, syphilis, mumps, herpes simplex and Epstein-Barr virus, adenovirus, Rickettsia, Sporothrix, Chlamydia infections). CASE REPORT We present the case of a 66-year-old man with granulomatous conjunctivitis and ipsilateral preauricular, submandibular, and upper cervical lymphadenopathies following a superficial corneal injury. Although the systematic amoxicillin/clavulanic acid and metronidazole antibiotic therapy started immediately at admission, the suppuration of the lymph nodes required surgical drainage. Based on his anamnesis (sheep breeding; a twig scratching his eye 2 days before the initial attendance) and symptoms, a zoonosis, namely the oculoglandular form of tularemia, was suspected, empiric ciprofloxacin therapy was administered, and the patient recovered without sequelae. The Francisella tularensis infection was eventually confirmed by microagglutination serologic assay. CONCLUSIONS If Parinaud oculoglandular syndrome is diagnosed and cat scratch fever as the most common etiology is not likely, other zoonoses, especially the oculoglandular form of tularemia, should be suspected. Serology is the most common laboratory method of diagnosing tularemia. Empiric fluoroquinolone (ciprofloxacin) or aminoglycoside (gentamicin or streptomycin) antibiotic therapy should be started immediately at the slightest suspicion of oculoglandular tularemia.

[Double hatchet flap for reconstruction of skin defects in head and neck skin cancer surgery]. / Kettos bárdlebeny alkalmazása fej-nyaki bortumorok mutéti defektusainak rekonstrukciójára.

INTRODUCTION: Skin cancers are the most common human neoplasms with head and neck localization in 90% of cases. Primary therapy is surgery, resulting in absolute skin defects in a number of cases. The reconstruction of these is performed with local skin flaps showing identical colour, texture and follicle density with the defect site. OBJECTIVE: In the present study, we report our preliminary experience with the head and neck application of double hatchet flap, a random pattern flap. METHOD: In our study, results of patients undergoing double hatchet flap reconstruction in the period between November 2021 and June 2023 were analyzed prospectively in terms of tumor site, defect size, method of anesthesia, and early and late complication rates. Patients followed up to a minimum of 6 months were asked to fill in a questionnaire concerning their postoperative status. RESULTS: A total of 13 patients with a mean age of 79.6 years underwent double hatchet flap reconstruction. The most frequent defect site was the scalp and the mean defect size was 40.5 × 32.1 mm. Histopathological examination showed R0 resection of the tumor in each case. The closure of the skin defect was insufficient in 1 case. Partial flap necrosis and mimical paralysis were observed as early and late complications in 2 cases, respectively. The most bothersome sequel reported by patients was scarring. DISCUSSION: For selection of a local flap, the following factors need to be considered: localization and size of the defect, skin elasticity, amount of adjacent skin to mobilize, direction of relaxed skin tension lines and wrinkles, and aesthetic units. If the principles of the hatchet flap design (the ratio of flap length and width and pedicle width to the defect size) are adhered, the resulting technique is reliable with an acceptable complication rate. CONCLUSION: The double hatchet flap as a random pattern flap is a fast, reliable technique especially for the closure of 2-5 cm skin defects of the scalp and forehead. Orv Hetil. 2023; 164(44): 1755-1763.