RESUMO
Neuroprotective properties of the new derivative of glutamic and apovincaminic acids, ethyl -(3-alpha,16-alpha)-eburnamenin-14-carbopxylate of 2-aminopentadionic acid (LHT 1-02) were studied on a model of acute brain ischemia in cats. LHT 1-02 has proved to be more effective than the reference drugs vinpocetin and glycine in preventing the reperfusive damage, which was manifested by decreased postischemic hyperglycemia, activated utilization of oxygen in the brain, and suppressed postischemic metabolic lactate acidosis. Thus, the results of this comparative study show expediency of further investigations of LHT 1 - 02 as a potential neuroprotective drug.
Assuntos
Isquemia Encefálica/tratamento farmacológico , Encéfalo/efeitos dos fármacos , Ácido Glutâmico/farmacologia , Fármacos Neuroprotetores/farmacologia , Traumatismo por Reperfusão/tratamento farmacológico , Alcaloides de Vinca/farmacologia , Acidose Láctica/prevenção & controle , Animais , Glicemia/metabolismo , Encéfalo/metabolismo , Isquemia Encefálica/metabolismo , Gatos , Ácido Glutâmico/análogos & derivados , Ácido Glutâmico/síntese química , Glicina/farmacologia , Ácido Láctico/antagonistas & inibidores , Ácido Láctico/biossíntese , Fármacos Neuroprotetores/síntese química , Consumo de Oxigênio/efeitos dos fármacos , Traumatismo por Reperfusão/metabolismo , Alcaloides de Vinca/químicaRESUMO
Neuroprotector properties of a new apovincaminic acid derivative (LHT 2 - 02) were studied on a model of acute brain ischemia in cats. LHT 2 - 02 has proved to be more effective than the reference drugs vinpocetin and glycine in preventing the reperfusive damage, which was manifested by decreased postishemic hyperglycemia and suppressed postishemic metabolic lactate acidosis.
