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1.
Nat Commun ; 8: 16010, 2017 07 13.
Artigo em Inglês | MEDLINE | ID: mdl-28703126

RESUMO

While the ocean's large-scale overturning circulation is thought to have been significantly different under the climatic conditions of the Last Glacial Maximum (LGM), the exact nature of the glacial circulation and its implications for global carbon cycling continue to be debated. Here we use a global array of ocean-atmosphere radiocarbon disequilibrium estimates to demonstrate a ∼689±53 14C-yr increase in the average residence time of carbon in the deep ocean at the LGM. A predominantly southern-sourced abyssal overturning limb that was more isolated from its shallower northern counterparts is interpreted to have extended from the Southern Ocean, producing a widespread radiocarbon age maximum at mid-depths and depriving the deep ocean of a fast escape route for accumulating respired carbon. While the exact magnitude of the resulting carbon cycle impacts remains to be confirmed, the radiocarbon data suggest an increase in the efficiency of the biological carbon pump that could have accounted for as much as half of the glacial-interglacial CO2 change.

2.
Nature ; 462(7271): 346-9, 2009 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-19924213

RESUMO

The release of fossil fuel CO(2) to the atmosphere by human activity has been implicated as the predominant cause of recent global climate change. The ocean plays a crucial role in mitigating the effects of this perturbation to the climate system, sequestering 20 to 35 per cent of anthropogenic CO(2) emissions. Although much progress has been made in recent years in understanding and quantifying this sink, considerable uncertainties remain as to the distribution of anthropogenic CO(2) in the ocean, its rate of uptake over the industrial era, and the relative roles of the ocean and terrestrial biosphere in anthropogenic CO(2) sequestration. Here we address these questions by presenting an observationally based reconstruction of the spatially resolved, time-dependent history of anthropogenic carbon in the ocean over the industrial era. Our approach is based on the recognition that the transport of tracers in the ocean can be described by a Green's function, which we estimate from tracer data using a maximum entropy deconvolution technique. Our results indicate that ocean uptake of anthropogenic CO(2) has increased sharply since the 1950s, with a small decline in the rate of increase in the last few decades. We estimate the inventory and uptake rate of anthropogenic CO(2) in 2008 at 140 +/- 25 Pg C and 2.3 +/- 0.6 Pg C yr(-1), respectively. We find that the Southern Ocean is the primary conduit by which this CO(2) enters the ocean (contributing over 40 per cent of the anthropogenic CO(2) inventory in the ocean in 2008). Our results also suggest that the terrestrial biosphere was a source of CO(2) until the 1940s, subsequently turning into a sink. Taken over the entire industrial period, and accounting for uncertainties, we estimate that the terrestrial biosphere has been anywhere from neutral to a net source of CO(2), contributing up to half as much CO(2) as has been taken up by the ocean over the same period.


Assuntos
Dióxido de Carbono/análise , Água do Mar/química , Dióxido de Carbono/metabolismo , Humanos , Modelos Teóricos , Oceanos e Mares , Fatores de Tempo
3.
CMAJ ; 165(5): 575-83, 2001 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-11563209

RESUMO

BACKGROUND: Delirium in older hospital inpatients appears to be associated with various adverse outcomes. The limitations of previous research on this association have included small sample sizes, short follow-up periods and lack of consideration of important confounders or modifiers, such as severity of illness, comorbidity and dementia. The objective of this study was to determine the prognostic significance of delirium, with or without dementia, for cognitive and functional status during the 12 months after hospital admission, independent of premorbid function, comorbidity, severity of illness and other potentially confounding variables. METHODS: Patients 65 years of age and older who were admitted from the emergency department to the medical services were screened for delirium during their first week in hospital. Two cohorts were enrolled: patients with prevalent or incident delirium and patients without delirium, but similar in age and cognitive impairment. The patients were followed up at 2, 6 and 12 months after hospital admission. Analyses were conducted for 4 patient groups: 56 with delirium, 53 with dementia, 164 with both conditions and 42 with neither. Baseline measures included delirium (Confusion Assessment Method), dementia (Informant Questionnaire on Cognitive Decline in the Elderly), physical function (Barthel Index [BI] and premorbid instrumental activities of daily living, IADL), the Mini-Mental State Examination (MMSE), comorbidity, and physiologic and clinical severity of illness. Outcome variables measured at follow-up were the MMSe, Barthel Index, IADL and admission to a long-term care facility. RESULTS: After adjustment for covariates, the mean differences in MMSE scores at follow-up between patients with and without delirium were -4.99 (95% confidence interval [CI] -7.17 to -2.81) for patients with dementia and -3.36 (95% CI -6.15 to -0.58) for those without dementia. At 12 months, the adjusted mean differences in the BI were -16.45 (95% CI -27.42 to -5.50) and -13.89 (95% CI -28.39 to 0.61) for patients with and without dementia respectively. Patients with both delirium and dementia were more likely to be admitted to long-term care than those with neither condition (adjusted odds ratio 3.18, 95% CI 1.19 to 8.49). Dementia but not delirium predicted worse IADL scores at follow-up. Unadjusted analyses yielded similar results. INTERPRETATION: For older patients with and without dementia, delirium is an independent predictor of sustained poor cognitive and functional status during the year after a medical admission to hospital.


Assuntos
Transtornos Cognitivos/etiologia , Delírio/complicações , Delírio/epidemiologia , Transtornos Psicomotores/etiologia , Atividades Cotidianas , Idoso , Idoso de 80 Anos ou mais , Transtornos Cognitivos/epidemiologia , Fatores de Confusão Epidemiológicos , Delírio/diagnóstico , Demência/complicações , Demência/diagnóstico , Demência/epidemiologia , Feminino , Avaliação Geriátrica , Hospitalização , Humanos , Incidência , Institucionalização , Modelos Logísticos , Masculino , Prevalência , Prognóstico , Estudos Prospectivos , Escalas de Graduação Psiquiátrica , Transtornos Psicomotores/epidemiologia , Fatores de Risco , Índice de Gravidade de Doença
4.
Arch Intern Med ; 161(8): 1099-105, 2001 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-11322844

RESUMO

BACKGROUND: Use of anticholinergic (ACH) medications is a biologically plausible and potentially modifiable risk factor of delirium, but research findings are conflicting regarding its association with delirium. OBJECTIVES: To evaluate the longitudinal association between use of ACH medications and severity of delirium symptoms and to determine whether this association is modified by the presence of dementia. PATIENTS AND METHODS: A total of 278 medical inpatients 65 years and older with diagnosed incident or prevalent delirium were followed up with repeated assessments using the Delirium Index for up to 3 weeks. Exposure to ACH and other medications was measured daily. The association between change in medication exposure in the 24 hours preceding a Delirium Index assessment was assessed using a mixed linear regression model. RESULTS: During follow-up (mean +/- SD, 12.3 +/- 7.0 days), 47 medications with potential ACH effect were used in the population (mean, 1.4 medications per patient per day). Increase in delirium severity was significantly associated with several measures of ACH medication exposure on the previous day, adjusting for dementia, baseline delirium severity, length of follow-up, and number of non-ACH medications taken. Dementia did not modify the association between ACH medication use and delirium severity. CONCLUSION: Exposure to ACH medications is independently and specifically associated with a subsequent increase in delirium symptom severity in elderly medical inpatients with diagnosed delirium.


Assuntos
Antagonistas Colinérgicos/efeitos adversos , Demência/complicações , Hospitalização , Idoso , Análise de Variância , Progressão da Doença , Feminino , Humanos , Modelos Lineares , Masculino , Fatores de Risco , Índice de Gravidade de Doença , Fatores de Tempo
5.
Can J Psychiatry ; 46(9): 819-28, 2001 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11761633

RESUMO

OBJECTIVE: To review systematically the psychosocial risk factors for poststroke depression. METHODS: Medline was searched using the key words "poststroke depression" (PSD) for the period January 1, 1966, to June 30, 2000; using the key words "cerebrovascular disease" and "depression" it was searched from June 1, 1996, to June 30, 2000. Corollary articles were obtained from the bibliographies. Inclusion criteria were as follows: original research in French or English; prospective, case-control or cross-sectional study design; assessment of PSD in the first 6 months following the stroke; an acceptable definition of depression; an acceptable definition of stroke; and at least one psychosocial risk factor. Interrater reliability was tested for the selection and quality of the articles. A qualitative risk factor analysis was conducted. RESULTS: The risk factors most consistently associated with PSD are a past history of depression, past personal psychiatric history, dysphasia, functional impairments, living alone, and poststroke social isolation. Risk factors not associated with PSD are dementia and cognitive impairment. Controversial risk factors are age, socioeconomic status (SES), prior social distress, dependency in regard to activities of daily living (ADL), and sex. CONCLUSIONS: Over approximately 30 years, some 25 qualitative studies have addressed psychosocial risk factors for PSD. Further studies should aim for quantitative analysis. The results suggest that identifying psychiatric history and preventing social deterioration and impairment should be part of multidisciplinary efforts to care for poststroke patients.


Assuntos
Transtorno Depressivo/diagnóstico , Papel do Doente , Meio Social , Acidente Vascular Cerebral/psicologia , Atividades Cotidianas/psicologia , Demência/diagnóstico , Demência/psicologia , Transtorno Depressivo/psicologia , Humanos , Fatores de Risco
6.
CMAJ ; 163(8): 977-81, 2000 Oct 17.
Artigo em Inglês | MEDLINE | ID: mdl-11068569

RESUMO

BACKGROUND: Delirium is a complex medical disorder associated with high morbidity and mortality among elderly patients. The goals of our study were to determine the prevalence of delirium in emergency department (ED) patients aged 65 years and over and to determine the sensitivity and specificity of a conventional clinical assessment by an ED physician for the detection of delirium in the same population. METHODS: All elderly patients presenting to the ED in a primary acute care, university-affiliated hospital who were triaged to the observation room on a stretcher because of the severity of their illness were screened for delirium by a research psychiatrist using the Mini-Mental State Examination and the Confusion Assessment Method. The diagnosis of "delirium" or an equivalent term by the ED physician was determined by 2 methods: completion of a mental status checklist by the ED physician and chart review. The prevalence of delirium and the sensitivity and specificity of the ED physician's clinical assessment were calculated with their 95% confidence intervals. The demographic and clinical characteristics of patients with detected delirium and those with undetected delirium were compared. RESULTS: A sample of 447 patients was screened. The prevalence of delirium was 9.6% (95% confidence interval 6.9%-12.4%). The sensitivity of the detection of delirium by the ED physician was 35.3% and the specificity, 98.5%. Most patients with delirium had neurologic or pulmonary diseases, and most patients with detected delirium had neurologic diseases. INTERPRETATION: Despite the relatively high prevalence of delirium in elderly ED patients, the sensitivity of a conventional clinical assessment for this condition is low. There is a need to improve the detection of delirium by ED physicians.


Assuntos
Delírio/epidemiologia , Serviço Hospitalar de Emergência , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Intervalos de Confiança , Confusão/diagnóstico , Confusão/epidemiologia , Delírio/diagnóstico , Demografia , Serviço Hospitalar de Emergência/estatística & dados numéricos , Feminino , Hospitais de Ensino , Humanos , Pneumopatias/diagnóstico , Pneumopatias/epidemiologia , Masculino , Prontuários Médicos , Entrevista Psiquiátrica Padronizada , Doenças do Sistema Nervoso/diagnóstico , Doenças do Sistema Nervoso/epidemiologia , Prevalência , Quebeque/epidemiologia , Sensibilidade e Especificidade , Índice de Gravidade de Doença , Método Simples-Cego
7.
Int Psychogeriatr ; 12(2): 231-47, 2000 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10937543

RESUMO

OBJECTIVES: To estimate the annual rate of change scores (ARC) on the Mini-Mental State Examination (MMSE) in Alzheimer's disease (AD) and to identify study or population characteristics that may affect the ARC estimation. METHODS: MEDLINE was searched for articles published from January 1981 to November 1997 using the following keywords: AD and longitudinal study or prognosis or cognitive decline. The bibliographies of review articles and relevant papers were searched for additional references. All retrieved articles were screened to meet the following inclusion criteria: (a) original study; (b) addressed cognitive decline or prognosis or course of AD; (c) published in English; (d) study population included AD patients with ascertainable sample size; (e) used either clinical or pathological diagnostic criteria; (f) longitudinal study design; and (g) used the MMSE as one of the outcome measures. Data were systematically abstracted from the included studies, and a random effects regression model was employed to synthesize relevant data across studies and to evaluate the effects of study methodology on ARC estimation and its effect size. RESULTS: Of the 439 studies screened, 43 met all the inclusion criteria. After 6 studies with inadequate or overlapping data were excluded, 37 studies involving 3,492 AD patients followed over an average of 2 years were included in the meta-analysis. The pooled estimate of ARC was 3.3 (95% confidence interval [CI]: 2.9-3.7). The observed variability in ARC across studies could not be explained with the covariates we studied, whereas part of the variability in the effect size of ARC could be explained by the minimum MMSE score at entry and number of assessments. CONCLUSIONS: A pooled average estimate of ARC in AD patients was 3.3 points (95% CI: 2.9-3.7) on the MMSE. Significant heterogeneity of ARC estimates existed across the studies and cannot be explained by the study or population characteristics investigated. Effect size of ARC was related to the initial MMSE score of the study population and the number of assessments.


Assuntos
Doença de Alzheimer/diagnóstico , Transtornos Cognitivos/diagnóstico , Testes Neuropsicológicos , Idoso , Humanos , Prognóstico , Índice de Gravidade de Doença
8.
Compr Psychiatry ; 41(1): 57-62, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10646620

RESUMO

The goal of this study is to replicate an earlier epidemiological finding of seasonal changes in mood and behavior among Chinese medical students using an independent study population. Three hundred nineteen college students were surveyed with a Chinese version of the Seasonal Pattern Assessment Questionnaire (SPAQ) and the Beck Depression Inventory (BDI) in Jining, China, during March of 1996. The frequency of seasonal patterns and prevalence rates of seasonal affective disorder (SAD) were estimated and compared with data from the medical student survey conducted in the same city. The mean Global Seasonality Score (GSS) of this college student sample was 9.9 +/- 4.9; 84% of the subjects reported some problems with the changing seasons. Summer difficulties were more prevalent than winter difficulties by a ratio of 1.9 to 1 (38.9% v 20.1%). The estimated rates of summer SAD and subsyndromal-SAD (s-SAD) were 7.5% and 11.9%, respectively, as compared with the corresponding winter figures of 5.6% and 6.3%. In addition, the prevalence estimates of winter pattern or winter SADs were higher in males than in females, but the corresponding summer figures showed no gender difference. Compared with the data from the medical student survey, this college student sample had a higher GSS (P < .01) but comparable summer to winter and female to male ratios for the prevalence of SADs (P > .05). These results replicate our previous findings that seasonal problems are common in China, but the predominant problems are summer difficulties rather than winter difficulties, and there is no female preponderance in the prevalence estimates of such problems. Both findings stand in contrast to most Western studies but are consistent with the only other published study performed in the Orient.


Assuntos
Afeto , Transtorno Afetivo Sazonal/epidemiologia , Estações do Ano , Estudantes/psicologia , Estudantes/estatística & dados numéricos , Adulto , China/epidemiologia , Comparação Transcultural , Feminino , Humanos , Masculino , Prevalência , Escalas de Graduação Psiquiátrica , Transtorno Afetivo Sazonal/etnologia , Universidades
10.
Can J Psychiatry ; 43 Suppl 1: 10S-14S, 1998 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-9773232

RESUMO

OBJECTIVE: To present a clinical case of an elderly person with psychosis and to discuss associated diagnostic and treatment issues. METHODS: A case from 1 of the authors' clinical practices was presented in English and French to several groups of Canadian psychiatrists attending a teaching day on psychosis. Three geriatric psychiatrists acted as facilitators, soliciting the clinical experiences of the participants in the discussion. The authors integrated clinical content from these sessions with results of a Medline search on psychosis in elderly persons. RESULTS: The assessment of elderly patients with psychosis is more often than in younger patients by overlying organicity, including delirium due to illness or medication use, dementia, or sensory deficits. Treatment might further worsen cognitive, affective, and functional impairment through adverse effects such as extrapyramidal symptoms (leading to decreased mobility and general functioning), anticholinergic effects (predisposing to delirium), and hypotension (predisposing to falls). Newer antipsychotics with less hazardous side effect profiles have an increasing role, but they must be coupled with psychosocial support to maximize the patient's independent functioning and quality of life after discharge. CONCLUSIONS: Assessment and treatment of the elderly person with psychosis must consider a wide variety of biopsychosocial variables, seeking to minimize further treatment-related deterioration. Controlled studies of antipsychotics in elderly people must be conducted in a variety of diagnostic situations that reflect their actual use in the community, and information must be propagated effectively among general psychiatrists, family physicians, and geriatric psychiatrists. The role of nonpharmacologic interventions in elderly persons with psychosis is even less well understood and deservers further study.


Assuntos
Antipsicóticos/uso terapêutico , Psiquiatria Geriátrica/métodos , Transtornos Psicóticos/terapia , Idoso , Idoso de 80 Anos ou mais , Antipsicóticos/efeitos adversos , Diagnóstico Diferencial , Feminino , Avaliação Geriátrica , Humanos , Transtornos Neurocognitivos/diagnóstico , Transtornos Neurocognitivos/terapia , Polimedicação , Psicoses Induzidas por Substâncias/diagnóstico , Psicoses Induzidas por Substâncias/terapia , Transtornos Psicóticos/diagnóstico , Transtornos Psicóticos/etiologia
11.
Int Psychogeriatr ; 10(3): 303-8, 1998 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-9785149

RESUMO

The clinical diagnosis of delirium has traditionally been based on an assessment by one or more physicians. Because of the transient, ubiquitous, and fluctuating nature of the symptoms of delirium, however, this approach may be flawed. Therefore, we decided to compare diagnosis based on one assessment by a psychiatrist, diagnosis by a nurse clinician (using the Confusion Assessment Method [CAM] and multiple observation points), and diagnosis by consensus. The study subjects were 87 patients aged 65 and over who were admitted consecutively from the emergency department to the medical wards, and who scored 3 or more on the Short Portable Mental Status Questionnaire. All subjects were assessed independently by one of three psychiatrists (a chart review and clinical examination) and a nurse clinician (using the CAM and multiple observation points). A consensus conference, attended by the three psychiatrists and the nurse clinician, used all available information to reach a consensus diagnosis. Compared to the consensus diagnosis, the clinical diagnosis by a psychiatrist had a sensitivity of .73 (95% confidence interval [CI]: .61-.85), a specificity of .93 (95% CI: .79-1.0), and an agreement kappa coefficient of .58 (95% CI: .41-.74). The nurse clinician diagnosis had a sensitivity of .89 (95% CI: .81-.97), a specificity of 1.00, and an agreement kappa coefficient of .86 (95% CI: .75-.97). These results suggest that one clinical assessment by a psychiatrist may not be the best method for detecting and diagnosing delirium in the elderly. A consensus diagnosis or diagnosis by a trained rater (using the CAM and multiple observation points) may be more sensitive approaches.


Assuntos
Confusão/diagnóstico , Delírio/diagnóstico , Avaliação Geriátrica , Entrevista Psiquiátrica Padronizada/normas , Enfermeiros Clínicos , Avaliação em Enfermagem/normas , Psiquiatria , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Variações Dependentes do Observador , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
12.
J Gen Intern Med ; 13(3): 204-12, 1998 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-9541379

RESUMO

OBJECTIVE: Delirium is frequent in elderly hospitalized patients. Many studies have examined its risk factors, but results have been quite variable. Thus, the goal of this study is to identify through systematic literature review the risk factors associated with the development of delirium in hospitalized geriatric patients. MEASUREMENTS AND MAIN RESULTS: First, MEDLINE/CURRENT CONTENTS databases were screened for relevant articles published from 1966 to December 1995, and from bibliographies of identified articles additional reports were selected. Second, the reports were screened by two different investigators and retained only if meeting the five following criteria: (1) original research in French or English; (2) prospective study; (3) patients over age 50; (4) minimum of one risk factor examined; (5) acceptable definition of delirium. Third, the methodology of each study was graded according to specific criteria for risk factor studies. Fourth, risk factors were identified and tabulated, unadjusted odds ratios (ORs) were computed, and where appropriate a combined OR with the Mantel-Haenszel estimator was calculated. Twenty-seven articles were retained meeting all of the above criteria. Among these studies, 11 were done on medical patients, 9 on surgical patients, 2 on medical and surgical patients, and 5 on psychiatric patients. In total 1,365 subjects with delirium were studied. Sixty-one different risk factors were examined, the five most common being dementia, medication, medical illness, age, and male gender. Mantel-Haenszel estimator was calculated for 10 risk factors, the most strongly associated being dementia (OR 5.2; 95% confidence interval [CI] 4.2, 6.3), medical illness (OR 3.8; 95% CI 2.2, 6.4), alcohol abuse (OR 3.3; 95% CI 1.9, 5.5), and depression (OR 1.9; 95% CI 1.3, 2.6). Methodologic weaknesses were present in many studies. CONCLUSIONS: Despite methodologic limitations, certain risk factors for delirium seem to be consistent and could help identify high-risk patients. These risk factors include dementia, advanced age, and medical illness. Other risk factors appear to play a contributory role in the development of delirium in elderly hospitalized patients.


Assuntos
Delírio/epidemiologia , Fatores Etários , Idoso , Feminino , Humanos , Pacientes Internados , Masculino , Fatores de Risco
13.
Int Psychogeriatr ; 10(4): 421-33, 1998 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-9924835

RESUMO

The objective of this study was to assess the psychometric properties of a new instrument, the Delirium Index (DI), to measure changes in the severity of the symptoms of delirium among patients previously diagnosed with delirium. Subjects were medical inpatients aged 65 and over diagnosed with delirium by the Confusion Assessment Method. Interrater reliability of the DI was .78 between research assistants (concordance coefficient) and was .88 between research assistants and geriatric psychiatrists. Criterion validity, assessed by the correlation between DI and Delirium Rating Scale scores (Spearman's correlation coefficient, r), was .84. Construct validity was assessed using correlations of the DI with two measures of current function for convergent validity (r = -.60, -.70) and two measures of function before admission for discriminant validity (r = .26,-.42). We conclude that the DI has acceptable levels of interrater reliability, criterion validity, and construct validity.


Assuntos
Delírio/diagnóstico , Avaliação Geriátrica , Escalas de Graduação Psiquiátrica/normas , Psicometria/normas , Índice de Gravidade de Doença , Idoso , Idoso de 80 Anos ou mais , Intervalos de Confiança , Feminino , Humanos , Masculino , Variações Dependentes do Observador , Estudos Prospectivos , Reprodutibilidade dos Testes
14.
J Geriatr Psychiatry Neurol ; 11(3): 126-37; discussion 157-8, 1998.
Artigo em Inglês | MEDLINE | ID: mdl-9894731

RESUMO

The purpose of this paper was to contribute to a new conceptual understanding of delirium by reviewing evidence related to its prevention, treatment, and outcome. The review process involved a systematic search of the literature on each topic, assessment of the validity of the studies retrieved, and examination of their results. The literature search identified 10 studies on prevention, 13 studies on treatment, and 15 studies on outcome. Most studies had methodological limitations. Abroad spectrum of interventions appeared to be modestly effective in preventing delirium in young and old surgical patients but not elderly medical patients; systematic detection and intervention programs and special nursing care appeared to add large benefits to traditional medical care in young and old surgical patients and modest benefits in elderly medical patients; haloperidol, chlorpromazine, and mianserin appeared to be useful in controlling the symptoms of delirium in both surgical and medical patients; and good levels of premorbid function seemed to be related to better outcomes. Although the above findings do not contribute to a new conceptual understanding of delirium, they do suggest directions for further research on the treatment of delirium.


Assuntos
Delírio/mortalidade , Delírio/terapia , Pacientes Internados/estatística & dados numéricos , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Ensaios Clínicos como Assunto/estatística & dados numéricos , Delírio/prevenção & controle , Feminino , Humanos , Institucionalização , Tempo de Internação , MEDLINE , Masculino , Pessoa de Meia-Idade , Avaliação de Processos e Resultados em Cuidados de Saúde/métodos , Fatores de Risco , Taxa de Sobrevida , Resultado do Tratamento
15.
CMAJ ; 155(9): 1263-8, 1996 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-8911292

RESUMO

OBJECTIVE: To determine the effectiveness of interventions to prevent delirium in hospitalized patients. DATA SOURCES: Two databases, MEDLINE and CINAHL, were searched for relevant articles published from January 1966 to May 1995 and from January 1982 to May 1995 respectively. The bibliographies of identified articles were searched for additional references. STUDY SELECTION: Ten articles met the following three inclusion criteria: (a) original research article, (b) published in English or French and (c) controlled trial (nonrandomized or randomized) of an intervention to prevent delirium in hospitalized patients. The validity of the studies was independently assessed according to the criteria for intervention studies proposed by the Evidence-Based medicine Working Group. DATA EXTRACTION: Information about study design, patient population, sample size, diagnostic criteria, interventions and results was systematically abstracted from each report. Absolute risk reduction (ARR) for delirium was calculated for each study. DATA SYNTHESIS: Eight trials involved surgical patients and two involved elderly medical patients; most of the studies had serious methodological limitations. Among the surgical patients the ARRs ranged from -13% to 81% and were not related to the type or timing of the intervention, or to the personnel involved. Among the elderly medical patients the ARRs ranged from -3% to 3%. CONCLUSION: Interventions to prevent delirium among surgical patients may be modestly effective, but further trials are necessary.


Assuntos
Delírio/prevenção & controle , Hospitalização , Humanos , Cuidados Pós-Operatórios , Cuidados Pré-Operatórios , Ensaios Clínicos Controlados Aleatórios como Assunto
16.
J Geriatr Psychiatry Neurol ; 9(2): 100-1, 1996 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-8736591

RESUMO

A previously healthy 82-year-old male presented with depressive and paranoid symptoms of 3 months' duration. Physical examination and cognitive functions were normal. Poor response to treatment and continuing weight loss lead to medical investigations that ultimately showed a large, left frontoparietal, chronic subdural hematoma. Following drainage, the patient showed some improvement in paranoid features but still required pharmacologic treatment for depression. The psychiatric features of chronic subdural hematoma as well as the management of this neurologic condition in the elderly patient are reviewed and discussed.


Assuntos
Hematoma Subdural/diagnóstico , Transtornos Neurocognitivos/diagnóstico , Idoso , Idoso de 80 Anos ou mais , Doença Crônica , Transtorno Depressivo/diagnóstico , Transtorno Depressivo/psicologia , Diagnóstico Diferencial , Hematoma Subdural/psicologia , Humanos , Masculino , Transtornos Neurocognitivos/psicologia , Transtornos Paranoides/diagnóstico , Transtornos Paranoides/psicologia
17.
CMAJ ; 151(7): 965-70, 1994 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-7922932

RESUMO

OBJECTIVE: To assess a systematic intervention in cases of delirium in elderly inpatients. DESIGN: Randomized, controlled trial. SETTING: University-affiliated, primary acute care hospital. PATIENTS: Patients aged 75 years or over admitted to the medical department. They were screened within 24 hours after admission, and 88 patients with delirium (according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, third revised edition) were detected and enrolled in the trial. The patients were randomly allocated to the treatment group (42) or the control group (46); all were followed up until the end of the study. INTERVENTION: Patients were assessed on enrolment and 1, 2, 4 and 8 weeks later. Those in the treatment group received a consultation by a geriatric internist or psychiatrist and follow-up by a liaison nurse. Those in the control group received regular medical care. OUTCOME MEASURES: Short Portable Mental Status Questionnaire (SPMSQ), Crichton Geriatric Behavioural Rating Scale (CGBRS), use of restraints, length of hospital stay, discharge to a setting providing more care than was needed before admission and mortality rate. RESULTS: Two weeks after admission, patients in the treatment group showed an improvement in their mean SPMSQ scores, from 8.2 (standard deviation [SD] 1.9) to 7.9 (SD 2.5), whereas the control group showed a deterioration, from 8.4 (SD 1.7) to 9.1 (SD 1.1); this difference had disappeared by the end of the 8-week period (p < 0.05). Mean CGBRS scores were higher in the treatment group (32.0 [SD 8.6]) than the control group (28.5 [SD 9.4]) on enrolment and had improved more markedly by the end of the 8-week period (to 23.9 [SD 7.8] v. 25.0 [SD 7.0], p = 0.06). There was no statistically significant difference between the groups in use of restraints, length of hospital stay, discharge to a setting providing more care than was needed before admission or mortality rate. CONCLUSION: The beneficial effects of systematic detection and intervention in cases of delirium in elderly inpatients were small.


Assuntos
Delírio/terapia , Pacientes Internados , Psicoterapia , Encaminhamento e Consulta , Idoso , Idoso de 80 Anos ou mais , Terapia Combinada , Delírio/diagnóstico , Delírio/etiologia , Delírio/mortalidade , Delírio/psicologia , Quimioterapia Combinada , Feminino , Seguimentos , Psiquiatria Geriátrica/métodos , Humanos , Testes de Inteligência , Tempo de Internação , Masculino , Análise Multivariada , Escalas de Graduação Psiquiátrica , Restrição Física , Fatores de Tempo , Resultado do Tratamento
18.
Can J Psychiatry ; 38(9): 584-6, 1993 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-8306229

RESUMO

A previously healthy elderly patient with a recent onset of macular degeneration presented for evaluation of elaborate complex visual hallucinations. The patient's psychiatric evaluation and level of cognitive functioning were normal. A diagnosis of organic hallucinosis secondary to macular degeneration was made, and the hallucinations ceased with increased sensory stimulation in the hospital. Numerous diagnoses were considered and are discussed, including Charles Bonnet hallucinations and peduncular hallucinosis.


Assuntos
Alucinações/fisiopatologia , Ataque Isquêmico Transitório/fisiopatologia , Transtornos Neurocognitivos/fisiopatologia , Privação Sensorial/fisiologia , Percepção Visual/fisiologia , Idoso , Idoso de 80 Anos ou mais , Mapeamento Encefálico , Tronco Encefálico/fisiopatologia , Córtex Cerebral/fisiopatologia , Corpos Geniculados/fisiopatologia , Alucinações/psicologia , Humanos , Ataque Isquêmico Transitório/psicologia , Masculino , Transtornos Neurocognitivos/psicologia , Isolamento Social , Síndrome , Acuidade Visual/fisiologia , Vias Visuais/fisiopatologia
19.
CMAJ ; 149(1): 41-6, 1993 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-8319153

RESUMO

OBJECTIVE: To determine the prognosis of delirium in elderly patients. DATA SOURCES: MEDLINE was searched for relevant articles published from January 1980 to March 1992. The bibliographies of identified articles were searched for additional references. STUDY SELECTION: Eight reports (involving 573 patients with delirium) met the following inclusion criteria: original research, published in English or French, prospective study design, diagnosis based on acute deterioration in mental state, sample of at least 20 patients, patients aged 60 years or over and follow-up of at least 1 week. The validity of the studies was independently assessed according to the criteria for prognostic studies established by McMaster University, Hamilton, Ont. No study met all the criteria. DATA EXTRACTION: Information about the patient sample, length of follow-up and results was systematically abstracted from each report and tabulated. DATA SYNTHESIS: A meta-analysis of the outcomes indicated that elderly patients with delirium had a mean length of stay of 20.7 days. One month after admission 46.5% were in institutions, and 14.2% had died; only 54.9% had improved mentally. Six months after admission 43.2% were in institutions. Compared with unmatched control subjects they had longer hospital stays, higher mortality rates at 1 month and higher rates of institutional care at 1 and 6 months. The presence of severe physical illness or dementia may have been related to some outcomes. CONCLUSIONS: Delirium in the elderly appears to have a poor prognosis. However, this finding may have been confounded by the presence of concomitant dementia or severe physical illness. Future studies must pay attention to methods and design, particularly the composition of study populations and the control of extraneous prognostic factors.


Assuntos
Delírio , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Delírio/diagnóstico , Delírio/epidemiologia , Feminino , Seguimentos , Hospitalização/estatística & dados numéricos , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos , Reprodutibilidade dos Testes
20.
Union Med Can ; 120(4): 302-6, 1991.
Artigo em Francês | MEDLINE | ID: mdl-1957418

RESUMO

During the past fifteen years, remarkable developments have occurred in Psychogeriatrics. Major advances have taken place in the biology of aging and the care of the elderly. Because of the demographic expansion of the geriatric population, psychiatrists and family physicians need to be familiar with the specific interventions which are available to tract the psychiatric problems of the elderly. Economic concerns should not distract attention from fundamental ethics issues connected with Psychogeriatrics. The intrinsic dignity of every human being must be recognized especially in the case of more vulnerable elderly patients. Such a conviction could prove essential as medicine and ethics face the new challenges that Psychogeriatrics will bring to Quebec int the next decades.


Assuntos
Ética Médica , Psiquiatria Geriátrica/tendências , Previsões , Psiquiatria Geriátrica/métodos , Psiquiatria Geriátrica/normas , Alocação de Recursos para a Atenção à Saúde , Defesa do Paciente , Quebeque
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