RESUMO
The pigmented purpuric dermatoses (PPD) are a group of disorders that most often occur on the lower extremities of middle-aged adults as asymptomatic, yellow-orange patches with petechiae. The PPD represent a benign, often chronic, capillaritis of unknown cause. We present a case of PPD on the abdomen of a young male and emphasize careful observation in such a patient to reveal possible progression to purpuric mycosis fungoides.
Assuntos
Transtornos da Pigmentação/patologia , Púrpura/patologia , Adulto , Humanos , Masculino , Transtornos da Pigmentação/complicações , Púrpura/complicações , Pele/patologiaAssuntos
Azatioprina/uso terapêutico , Imunossupressores/uso terapêutico , Penfigoide Bolhoso/tratamento farmacológico , Psoríase/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Azatioprina/administração & dosagem , Membrana Basal/patologia , Complemento C3c/análise , Feminino , Técnica Direta de Fluorescência para Anticorpo , Humanos , Imunoglobulina G/análise , Imunossupressores/administração & dosagem , Masculino , Pessoa de Meia-Idade , Penfigoide Bolhoso/complicações , Penfigoide Bolhoso/patologia , Psoríase/complicaçõesRESUMO
We describe a fatal case of low-dose methotrexate (MTX) toxicity in a patient with psoriasis, emphasizing the factors that exacerbate MTX toxicity and presenting rescue techniques. The patient had a toxic epidermal necrolysis-like condition. MTX cutaneous reactions ranging from toxic epidermal necrolysis to specific ulcerations have been described. The use of granulocyte colony stimulating factor for leukopenia associated with MTX toxicity is discussed.
Assuntos
Metotrexato/efeitos adversos , Psoríase/tratamento farmacológico , Síndrome de Stevens-Johnson/etiologia , Idoso , Fator Estimulador de Colônias de Granulócitos/uso terapêutico , Humanos , Masculino , Metotrexato/administração & dosagem , Síndrome de Stevens-Johnson/terapiaRESUMO
BACKGROUND: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is known to be a contact sensitizer. It is used extensively in cosmetic products in low concentrations. Occupational exposure usually occurs with concentrated solutions and results in a different reaction pattern. RESULTS: Three workers developed chemical burns and subsequent sensitization after exposure to concentrated solutions of MCI/MI. One patient was also occupationally sensitized to methyldibromoglutaronitrile/phenoxyethanol. CONCLUSION: Exposure to concentrated solutions of some allergens can be severely irritating in the occupational setting and can probably induce sensitization.