Assuntos
Coleta de Amostras Sanguíneas/instrumentação , Géis , Potássio/sangue , Idoso , Centrifugação , Reações Falso-Positivas , Humanos , MasculinoRESUMO
The correct clinical interpretation of serum total thyroxine requires a knowledge of the thyroxine binding globulin (TBG) concentration. An immunoelectrophoretic method for TBG assay has been assessed under routine conditions for precision, sensitivity and recovery. TBG has been compared with T3 Resin Uptake for euthyroid subjects, and patients with myxoedema and thyrotoxicosis. The relationship between TBG and age has also been studied. The method proved to be reliable, sensitive and a technically simple method for the routine determination of TBG and an excellent replacement for the indirect T3 Resin Uptake Test.
Assuntos
Soroglobulinas/análise , Proteínas de Ligação a Tiroxina/análise , Adolescente , Adulto , Idoso , Envelhecimento , Criança , Pré-Escolar , Feminino , Humanos , Hipertireoidismo/sangue , Hipotireoidismo/sangue , Imunoeletroforese , Lactente , Recém-Nascido , Masculino , Métodos , Pessoa de Meia-Idade , Fatores Sexuais , Tri-IodotironinaRESUMO
The relationship between serum thyroxine (T4) and thyroxine-binding globulin (TBG) has been studied in "euthyroid" subjects. The T4/TBG ratios in these subjects has been calculated and compared with those found in patients suffering from myxoedema and thyrotoxicosis. The ratio allows a more precise selection of the borderline cases requiring Thyroid Stimulating Hormone and triiodothyronine assays, particularly when the serum TBG is raised or lowered.
