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2.
Gig Sanit ; (10): 72-5, 1991 Oct.
Artigo em Russo | MEDLINE | ID: mdl-1806434

RESUMO

A new hormonal preparation--Yuvemon (analog of methoprene)--insecticide for mosquito larvae was synthesized in USSR. LD50 for rat is 25,000 mg/kg. Safety of the preparation was demonstrated.


Assuntos
Metoprene/análogos & derivados , Metoprene/toxicidade , Animais , Feminino , Dose Letal Mediana , Metoprene/administração & dosagem , Coelhos , Ratos
3.
Gig Sanit ; (3): 26-8, 1989 Mar.
Artigo em Russo | MEDLINE | ID: mdl-2744499

RESUMO

Proceeding from the experimental study carried out on the model of aniline methemoglobinemia, it was shown that the animals with low aniline-related resistance also had aniline low-resistant posterity during two following generations and vice versa high-resistant animals had the more aniline-resistant posterity. It was determined both by methemoglobin levels and by the number of animals with different methemoglobin levels. According to the degree of aniline-induced methemoglobinemia the correlation among three generations of animals was established.


Assuntos
Compostos de Anilina/toxicidade , Modelos Animais de Doenças , Hipersensibilidade a Drogas/genética , Metemoglobinemia/induzido quimicamente , Pais , Efeitos Tardios da Exposição Pré-Natal , Animais , Resistência a Medicamentos , Feminino , Masculino , Metemoglobinemia/genética , Gravidez , Ratos
4.
Gig Sanit ; (2): 9-11, 1989 Feb.
Artigo em Russo | MEDLINE | ID: mdl-2714674

RESUMO

An experimental evaluation of the impact of a number of chemical compounds toxicologically attributed to different hazardous classes on animal resistibility to influenza virus showed that resistibility dependence on the dose and effect duration had a nonlinear character. There was no complete correlation of a hazardous class of chemical substances and their impact on body resistibility to respiratory infections.


Assuntos
Etilenoglicóis/farmacologia , Formaldeído/farmacologia , Chumbo/farmacologia , Infecções por Orthomyxoviridae/imunologia , Animais , Relação Dose-Resposta a Droga , Etilenoglicóis/administração & dosagem , Formaldeído/administração & dosagem , Imunidade Inata/efeitos dos fármacos , Chumbo/administração & dosagem , Camundongos , Infecções por Orthomyxoviridae/prevenção & controle
11.
Tsitol Genet ; 16(2): 6-9, 1982.
Artigo em Russo | MEDLINE | ID: mdl-7101452

RESUMO

The paper deals with the influence of 1-month pretreatment of mice with different regimes of long-wave UV-radiation on spontaneous and cyclophosphamide (CP) induced levels of chromosome aberrations in the bone marrow cells. The level of aberrant cells in the bone marrow of control and CP treated mice was not changed by the suberythematous dose (0.5 of the erythematous dose) of UV-radiation. The mice pretreatment with 3 erythematous doses of UV-radiation significantly increased spontaneous and CP induced level of cells with chromosome aberrations as compared with that in UV-unexposed mice.


Assuntos
Medula Óssea/efeitos da radiação , Aberrações Cromossômicas , Ciclofosfamida/farmacologia , Raios Ultravioleta , Animais , Medula Óssea/efeitos dos fármacos , Relação Dose-Resposta a Droga , Relação Dose-Resposta à Radiação , Camundongos
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