RESUMO
DESIGN: A single-blind comparative prospective randomised clinical trial. OBJECTIVE: To evaluate the efficacy and safety of Russian muscular relaxant (Kruarone) in comparison with Esmerone in multicomponent balanced anesthesia during laparoscopic cholecystectomy. 80 patients (23-68 years old) were examined. The patients were randomized into two equal groups. The results showed that Kruarone was effective relaxant with rapid onset of action, providing optimal conditions for muscle relaxation for laryngoscopy and tracheal intubation. Kruarone did not require frequent administration supports, providing high quality and stable neuromuscular blockade during surgery. There was no any one case of adverse events for the entire period of 24-hour surveillance, the drug has no cumulative effect. Kruarone did not cause allergic reactions and had no significant effect on hemodynamics. Thus Kruarone 0.6 mg/kg with an average total flow rate of the drug within 55 mg (39.6-75.43 mg) has the same effectiveness and safety with Esmerone in similar dosages.
Assuntos
Androstanóis/uso terapêutico , Anestesia Geral/métodos , Colecistectomia Laparoscópica/métodos , Intubação Intratraqueal , Fármacos Neuromusculares não Despolarizantes/uso terapêutico , Adulto , Idoso , Extubação , Androstanóis/administração & dosagem , Androstanóis/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fármacos Neuromusculares não Despolarizantes/administração & dosagem , Fármacos Neuromusculares não Despolarizantes/efeitos adversos , Estudos Prospectivos , Rocurônio , Método Simples-Cego , Resultado do Tratamento , Adulto JovemRESUMO
The influence of domestic preparation "Cytoflavin" on the course of total intravenous anesthesia was studied in operations of mean duration in 30 patients. It was found that cytoflavin did not influence the need of anesthetic and narcotic analgetic, had cardioprotective effect and stabilized the hemodynamic parameters, the intraoperative frequency of critical incidents became 1.8-2.3 times less (p = 0.028), increasing safety of anesthesia, positively influenced the course of the postanesthetic rehabilitation, made the period of recovery 2 times shorter and the terms of extubation, orientation and readiness of the patient to transportation 1.6 times shorter.
Assuntos
Anestesia Intravenosa/métodos , Colecistectomia Laparoscópica , Mononucleotídeo de Flavina/administração & dosagem , Cálculos Biliares/cirurgia , Inosina Difosfato/administração & dosagem , Niacinamida/administração & dosagem , Succinatos/administração & dosagem , Adulto , Período de Recuperação da Anestesia , Método Duplo-Cego , Combinação de Medicamentos , Feminino , Seguimentos , Humanos , Injeções Intravenosas , Masculino , Pessoa de Meia-Idade , Monitorização Intraoperatória , Estudos Prospectivos , Resultado do Tratamento , Adulto JovemRESUMO
Catecholamines and intracardiac hemodynamics were studied in 37 patients with congenital heart defects. Clinical investigation confirmed importance of assessment of functional state of myocardium based on information, obtained by measurement of catecholamines in the heart. Concentration of catecholamines among various nosological was affected by perfusion and hypoxia of myocardium as well as forms of hyperfunction of cardiac muscle.
