[Design of topically resorptive interferon drugs]. / Sozdanie lekarstvennykh preparatov interferona mestno-rezorbtivnogo deistviia.

The current data on the development and design of topically resorptive interferon drugs are summarized. In many cases it is advisable to use topically resorptive interferon agents which allows them to topically affect a clinical process, to avoid negative sequelae seen when high-dose interferon is unjustifiably systematically given, by reducing its use to a minimum. Interferon is known to be one of the best antiviral agent, besides, it produces marked antimicrobial and antitumor effects. Whether interferon as a component of drugs can be stabilized by axillaries of various chemical nature which act as stabilizers, promoters, and carriers is dealt with. The topically resorptive formulations designed in terms of biopharmaceutical factors are described. The advantages of topically resorptive agents over other drugs are shown and hence they can be widely used in practical medicine.

[The effect of interleukin-2 on interferon production by human lymphocytes and the importance of this test in autoimmune diseases]. / Izuchenie vliianiia interleikina-2 na produktsiiu interferona limfotsitami cheloveka i znachenie etogo testa pri autoimmunnykh zabolevaniiakh.

Interleukin-2 (IL-2) was demonstrated to induce interferon (IFN) production in the cultured lymphocytes from healthy donors and myasthenia gravis (MG) patients. Moreover, IL-2 enhanced lymphocytic IFN production in patients and healthy individuals in response to phytohemagglutinin and concanavalin A. However, in MG patients, IFN production in response to IL-2 alone or in combination with mitogens is several times lower than that in healthy donors. This lowered IFN production in MG patients is accompanied by much higher rates of lymphocytic proliferation and by considerably enhanced spontaneous lymphocytic production of C-reactive protein as compared with healthy individuals. This test may be of great value in establishing the diagnosis of an autoimmune disease, in defining its severity and in evaluating the efficiency of therapy.

[Suppression of DNA synthesis in lymphocytes by UV-irradiated plasma]. / Podavlenie sinteza DNK v limfotsitakh plazmoi, podvergnutoi UF-oblucheniu.

The autologous plasma, isolated upon UV-irradiation of the whole blood, has an inhibitory effect on mitogen-induced, blastogenesis of human lymphocytes. Its addition to the culture medium results in a statistically significant suppression of DNA synthesis in lymphocytes in the presence of phytohemagglutinin and concanavalin A. No such effect was observed with the use of pokeweed mitogen. Our studies show that this phenomenon is associated with photoconversion of the plasma components.