[Effect of kontrikal on the course of experimental nonspecific phacogenic uveitis]. / Vliianie kontrikala na techenie nespetsificheskogo fakogennogo uveita v éksperimente.

Nonspecific phacogenic uveitis (NPGU) was simulated in 21 chinchilla rabbits to follow the time course of the blood serum proteolytic activity and the principal protease inhibitors (alpha 1 inhibitor and alpha 2 macroglobulin) in various stages of the inflammatory process. Effects of contrykal, a synthetic protease inhibitor, on these parameters and the course of the inflammation was also under study. The results evidence that i.v. and subconjunctival contrykal administration reduced the periods of NPGU treatment 1.5-2 times.

[Pancreatic kallikrein, a protector of small intestine damage in post-ischemic toxemia]. / Pankreaticheskii kallikrein--protektor povrezhdeniia tonkogo kishechnika pri postishemicheskoi toksemii.

The morphofunctional state of the small intestine was studied on a tourniquet shock model. The development of postischemic toxemia is followed by disorders of microcirculation leading to irreversible changes in the small intestine. The processes are associated with an increase of the proteolytic activity of the intestinal contents. An oral administration of andecaline prevents ischemia of the intestine, contributes to the preservation of its mucosa.

[Effect of alpha 2-macroglobulin on indices of the proteolysis system and organ blood flow in tourniquet shock]. / Vliianie al'fa 2-makroglobulina na pokazateli sistemy proteoliza i organnogo krovotoka pri turniketnom shoke.

It was shown that alpha 2-macroglobulin (50 mg/kg, 30 min before revascularization of previously ischemized extremities) significantly inhibits the blood serum proteolytic activity and exerts similarly to contrykal (10,000 U/kg) the correcting effect on the level of arterial blood pressure and parameters of the blood flow in the kidneys, intestine and previously ischemized extremities.

[Effect of kontrikal on the dynamics of proteolytic system indices in postischemic toxemia]. / Vliianie kontrikala na dinamiku pokazatelei sistemy proteoliza pri postishemicheskoi toksemii.

It was shown in Wistar male rats that the development of tourniquet shock was followed by an increase of proteolytic activity in the blood by 3 times, activity of aspartate aminotransferase (AST) by 3 times, that of alanine aminotransferase (ALT) by 6 times, contents of urea and residual nitrogen by 2.5-3 times; level of alpha 1-protease inhibitor (alpha 1-PI) decreased by 4 times and that of alpha 2-macroglobulin (alpha 2MG) by 2.5 times. At administration of contrykal (10,000 U/kg) proteolytic activity increased only by 32.5%, content of alpha 1-PI decreased only by 10-20% and level of alpha 2-MG did not differ from that in healthy animals. Activity of AST and ALT remained high, and contents of urea and residual nitrogen were near-normal.

[Effect of trypsin, kallikrein and kontrikal on the enzyme activity and cationic protein content of the blood neutrophils]. / Vliianie tripsina, kallikreina i kontrikala na aktivnost' nekotorykh fermentov i soderzhanie kationnykh belkov v neitrofilakh krovi.

It was shown on Wistar rats that trypsin and kallikrein decrease the activity of lactate dehydrogenase, alpha-glycerophosphate dehydrogenase, glycogen content and increase the activity of succinate dehydrogenase in neutrophils.