[Multiple sclerosis: its prevalence and incidence in the population of western Poland]. / Stwardnienie rozsiane--rozpowszechnienie i zapadalnosc wsród ludnosci miejscowej w zachodniej Polsce.

In five provinces of Western Poland the incidence and prevalence of multiple sclerosis was analyzed in patients living at the place of birth and in patients who had changed their place of residence in these provinces. The results showed that the occurrence of multiple sclerosis in geographic foci is more evident if all patients living in a given area are considered, both those born there and those who had come from other localities.

[Incidence of malignant neoplasms in patients with multiple sclerosis]. / Czestosc zachorowan na nowotwory zlosliwe u chorych na stwardnienie rozsiane.

The incidence of malignant neoplasma was determined in patients with multiple sclerosis in epidemiological studies in 717 patients. No significant difference was found from the general population aged over 15 years. This seems to suggest that immunosuppression resulting from corticotherapy has no effect increasing the risk of malignant neoplasm development in multiple sclerosis.

Contribution to the epidemiology of multiple sclerosis in Poland.

An epidemiological survey of multiple sclerosis was carried out in western Poland. Uneven local distribution of MS was found within 198 communes making up the territory. The disease was less frequent in 1981 than in 1965. A marked increase of population in age classes under 20 during the last decade may account for the observed differences in the prevalence rate. In the town of Gniezno, a new MS cluster was discovered.

[Further epidemiological studies of primary neoplasms of the nervous system in western Poland]. / Dalsze badania epidemiologiczne pierwotnych nowotworów ukladu nerwowego w zachodniej Polsce.

In West Poland with population on the day of the evaluation of 3,097 thousand the incidence of primary neoplasms of the nervous system was calculated in 5 large administration units (provinces) and in 224 smaller units (communities). The testing of the hypothesis of the equal distribution in the communities demonstrated differences, and in 10 of them this incidence was significantly higher above the mean. The main conclusion of the study is that nervous system neoplasms, 90% of which were located intracranially in our material may occur in foci or clusters of clinical as well as statistical significance.

Epidemiology of multiple sclerosis in western Poland--a comparison between prevalence rates in 1965 and 1981.

An epidemiological survey of multiple sclerosis was carried out in the western part of Poland. The estimated prevalence rate on December 31, 1981 was compared with that established on the same territory on January 1, 1965. The disease was less frequent in 1981. The prevalence rate for definite cases was only 42.87 versus 51.19. A marked increase of population in the younger age groups (those under 20) during the last decade may account for the observed differences in the prevalence rate. In the town of Gniezno, a new MS cluster with a prevalence rate of 118.10 per 100,000 population was discovered.

On the fine structure of the distribution of primary nervous system neoplasms in Western Poland.

The incidence rates of primary nervous system neoplasms in 5 districts (large administrative units) of Western Poland with a relatively homogeneous health care system but some contrasts in economic activity, as well as in 224 communes (smallest administrative units) located within these 5 districts, with a total population of 3,097,000 were estimated on the appointed day (31.12.79). Testing the hypothesis, assuming a homogeneous distribution of nervous system neoplasms over the region under investigation, that the incidence rates were distributed as a Poisson variable has revealed a focal distribution of these tumours; in 15 communes the frequency was higher than 9.0 and deviated from the remainder in the 5% right tail of the distribution. The main conclusion from the presented results was that tumours of the nervous system, of which 90% were intracranially located, may occur in clusters or foci, and this could prove to be of clinical as well as statistical import.

The clustering of multiple sclerosis in various administrative subunits of western Poland.

A survey of multiple sclerosis was made in the western part of Poland, with special attention being paid to the distribution of the disease in various administrative subunits. The prevalence of MS for the 35 counties (mean 45.08 per 100,000 for definite and possible cases taken together) revealed significant differences between particular regions, with clusters of high prevalence rates occurring in two towns (Leszno, 130,97; Gniezno, 122.83). Local uneven distribution of multiple sclerosis was also found within 198 communes covering the territory of the 35 counties. There were four clusters in eight neighbouring towns and communes with a high prevalence ranging from 74.37 to 141.54, and several with a very low prevalence.

[Primary tumors of the nervous system in the light of an epidemiologic analysis]. / Primäre Tumoren des Nervensystems im Licht einer epidemiologischen Analyse.

On a territory of 5 districts of western Poland with 3.097 thousands of inhabitants the annual incidence rates per 100 thousands of population as well as the prevalence rates of primary neoplasms have been determined. The results of our investigation have shown that multiforme glioblastomas and astrocytomas occurred in the investigated population with the highest annual incidence rates, whereas the highest prevalence rates were found for hypophyseal adenomas, to be followed by astrocytomas, meningiomas and glioblastoma multiforme. The obtained results are critically discussed and compared with epidemiological data presented by other authors who based on records from neurosurgical departments and autoptic sections, it is concluded that the presented results do reflect objectively the epidemiological situation of Poland.

[Current diagnosis of Schilder's disease]. / Przyczynek do wspólczesnej diagnostyki choroby Schildera.

Modern diagnosis of Schilder's disease is based on elimination by enzymatic test of the metabolic forms of diffuse sclerosis and elimination of subacute sclerosis panencephalitis with EEG investigations and determination of measles antibodies, demonstration by computer tomography of demyelination foci, and demonstration of typical changes in visual and auditory evoked potentials. Correct diagnosis of Schilder's disease opens the possibility of tentatives of treatment with immunosuppression, plasmapheresis and lymphocytopheresis.