RESUMO
A new method for fast 2D Electron Paramagnetic Resonance Imaging (EPRI) is presented. To reduce the time of projections acquisition we propose to combine rapid scan of Zeeman magnetic field using high frequency sinusoidal modulation with simultaneously applied magnetic field gradient, whose orientation is changed at low frequency. The correctness of the method is confirmed by studies carried out on a phantom consisting of two LiPc samples. The images from the acquired data are reconstructed using iterative algorithms. The proposed method allows to reduce the image acquisition time up to 10 ms for 2D EPRI, and to detect the sinogram with infinitesimal angular step between projections.
RESUMO
A new method for fast spectral-spatial electron paramagnetic resonance imaging (EPRI) is presented. To reduce the time of projections acquisition we propose to combine rapid scan of Zeeman magnetic field using high frequency sinusoidal modulation with simultaneously applied magnetic field gradients, whose amplitude is modulated at low frequency. The correctness of the method is confirmed by studies carried out on a phantom consisting of two LiPc samples. The spectral-spatial images from the acquired data are reconstructed using iterative algorithms. The proposed method allows to acquire the spectral-spatial image with 800 projections at 200ms.
RESUMO
The synthesis of 11 new N-substituted derivatives of (E)-4'-hydroxy-3'-methoxystilbazoles-4 and their antimicrobial activity are reported. The relationships between structure and antibacterial activity are studied. In particular, compounds 5, 7 and 8 showed good antibacterial activity against Staphylococcus aureus, Streptococcus faecalis and Bacillus subtilis, while compound 6 did so against S. aureus and S. faecalis.
Assuntos
Antibacterianos/farmacologia , Halogênios/química , Piridinas/farmacologia , Antibacterianos/química , Bacillus subtilis/efeitos dos fármacos , Enterococcus faecalis/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Piridinas/química , Staphylococcus aureus/efeitos dos fármacos , Relação Estrutura-AtividadeRESUMO
The synthesis of 15 new N-benzyl substituted derivatives of (E)-gamma-azastilbenols-2'(3' and 4') and their antimicrobial activity are reported. In particular, compounds 1a-c, 1h and 2a-b showed good antibacterial activity against Staphlococcus aureus.
Assuntos
Antibacterianos/síntese química , Bactérias/efeitos dos fármacos , Antibacterianos/química , Antibacterianos/farmacologia , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Conformação Molecular , Espectrofotometria Infravermelho , Espectrofotometria UltravioletaRESUMO
The synthesis of 19 new N-substituted derivatives of (E)-alpha and gamma-azastillbenols-2'(3' and 4') and their antimicrobial activity are reported. In particular, compounds 4a-4f and 6a showed good antibacterial activity against Staphylococcus aureus, Streptococcus faecalis, Bacillus subtilis and Escherichia coli.
