Homocysteine and alpha-1 antitrypsin concentration in patients with subclinical hypercortisolemia.

PURPOSE: Glucocorticoids have particularly strong impact on the thromboembolic complications. A factor which increases the risk of thrombosis is hyperhomocysteinemia, observed in patients with hypercortisolemia. Proinflammatory factors also affect the haemostatic balance. There has been an extensive research which estimates hemostatic system in patients with Cushing's syndrome. Undoubtedly, much fewer publications are available on thromboembolic complications in patients with Subclinical Cushing's Syndrome (SCS). The purpose of this study was to estimate of homocysteine (HCY) and alpha-1 antitrypsin (α1ATp) concentrations in patients with SCS. MATERIALS AND METHODS: We studied 35 patients (56.0 ± 15.0 years) with SCS and 33 healthy volunteers (53.3 ± 17.7 years). In all subjects the analysis of HCY and α1ATp concentration in serum was determined with an immunonephelometric method. P-values below 0.05 were considered statistically significant. RESULTS: A comparison of HCY and α1ATp mean concentrations in patients with SCS and healthy representatives indicated statistically higher values of both analysed parameters in the sera of patients than in the healthy controls (p values were 0.018 and 0.008, respectively). In the patients with SCS a negative correlation between α1ATp and cortisol concentration in overnight dexamethasone test was found (p=0.017, R=-0.40). We did not reveal any statistically significant correlation between the concentrations of HCY and α1ATp, and coagulation parameters such as INR, APTT, fibrinogen concentration in patients with SCS. CONCLUSIONS: On the basis of the obtained results, a slight increase in the concentration of homocysteine and α1ATp is observed in patients with SCS, which may influence vascular complications.

[The relationship between intraperitoneal adhesion index and anatomical status of oviductal ampullary mucosa in patients with distal tubal occlusion]. / Zwizek miedzy wskaznikiem zrostów wewnatrzotrzewnowych a stanem anatomicznym banki jajowodów niedroznych w ujsciu brzusznym.

OBJECTIVES: An effort was made to verify co-relation between intraperitoneal adhesions and anatomy of oviductal mucosa of infertile women with distal tubal occlusion. MATERIALS AND METHODS: The study comprised 25 infertile women with distal tubal occlusion. The patients were allocated into 3 groups: A--11 women with the history of pelvic inflammatory disease (PID); B--9 patients with previous gynecological abdominal surgery; and C--5 women without PID nor surgery. Intraperitoneal adhesion index as well as oviductal mucosa were evaluated during laparoscopy and salpingoscopy. RESULTS: Women with the history of PID presented strong co-relation between intraperitoneal adhesions and anatomical abnormalities of the tubal mucosa with distal tubal occlusion. The co-relation was stronger then in women with previous abdominal surgery. Following the evaluation of the fallopian tubes, 5 out of 11 patients with history of PID, 6 of 9 women with history of previous surgery and all 5 without any risk factors were qualified for microsurgical reconstructive treatment. The remaining patients were sent for in vitro fertilization and embryo transfer.

[Polymorphism of vitamin D receptor Bsm I gene and of estrogen receptor Xba I and Pvu II gene in girls and women with low bone mass]. / Polimorfizm Bsm I genu receptora witaminy D oraz Xba I i Pvu II genu receptora estrogenow u dziewczat z niska masa kostna.

We investigated the vitamin D receptor (VDR) and the estrogen receptor (ER) genes polymorphism in studied groups was similar, however the allelic combination BBPPxx was associated with low bone mineral mass. There is a need to perform genetic test in the cohort of polish women endangered by osteoporosis.