[Young patients after myocardial infarction--what could be done?]. / Mlodzi pacjenci z zawalem miesnia sercowego--czy moina cos zrobic?

INTRODUCTION: The cause of myocardial infarction is a sudden necrosis of blood arteries which delivery blood to heart, what suddenly begins necrosis of this area, that is a formation necrosis. Myocardial infarction can step out both in persons with coronary disease diagnosis and at young person so far have not any symptoms from side circulation system. MATERIAL AND METHODS: The study was applied 37 young patients (7 women and 30 men) from II Clinical and Cathedral of Cardiology in Zabrze of The Silesian Medical University in Katowice with myocardial infarction. In this work the authors used the questionnaire which including basic information about hospitalized patients as well as executed the retrospective opinion of chosen risk factors (dyslipidemia, diabetes mellitus, hypertension arterials, family interview and smoking). The authors were also executed qualification of frequency the type of myocardial infarction, diagnostic and therapeutic conduct with cardiologic interview in three aged groups (to 30 years of age, 31-35 years of age, 36-40 years of age). RESULTS: The five-year-old observation showed, that the smoking was the strongest risk factor, the raised level of cholesterol as well as the burdening family interview. It surprises however the lack of relationship with diabetes. In diagnostic ad therapeutic conduct the fundamental part play coronarography examination and PCI procedure. CONCLUSIONS: The creature of counteract in myocardial infarction in young people before 40 years old should be preventive action under propagating the healthy style of life aspect (the education, diet, physical activity) as well as the modification of reversible risk factors, which will permit to reduce or they will stop the intensive development of cardiac-vascular diseases.

[The usefulness of the 6-minute walk test in patients with chronic heart failure in 6-month observation]. / Przydatnosc 6-minutowego testu spacerowego w ocenie zmian w stanie klinicznym chorych z niewydolnoscia serca podczas 6-miesiecznej obserwacji.

UNLABELLED: The severity of chronic heart failure (CHF) is usually evaluated by using the New York Heart Association (NYHA) classification. However this method is not good to assess the efficacy of therapy. There is no correlation between the severity of CHF measured by echocardiographic examination of left ventricular ejection fraction (LVEF) and NYHA classification. We investigated the usefulness of the 6-minute walk test to determinate the physical activity in patients with CHF. Studies were performed in 50 patients with symptomatic CHF and LVEF no more than 45%. Six-minute walk test, assessment of NYHA class and LVEF were performed. Changes in the treatment were done between first and second part of the investigation. We observed some changes in LVEF value (between the 1st and the 2nd stage of our study) as well as in NYHA classification (between the 1st and the 2nd stage and between the 2nd and the 3rd stage). We did not noticed essential changes in 6-minute walk tests results. We observed negative correlation between the distance walked in six-minute walk test and the NYHA class in examined patients through all study time. There was some dependence indicated between the LVEF and the 6-minute walk test distance in the first stage. CONCLUSIONS: The severity of CHF graded with NYHA classification correlates with the 6-minute walk test distance in patients with CHF. The dependence between LVEF, NYHA class and 6-minute walk test results in treated patients with CHF diminish.

[Effect of hyperglycemia on glutathione peroxidase and superoxide dismutase activity in patients with newly diagnosed carbohydrate metabolism disturbances]. / Wplyw hiperglikemii na aktywnosc peroksydazy glutationowej i dysmutazy ponadtlenkowej u osób z swiezo rozpoznanymi zaburzeniami gospodarki weglowodanowej.

The aim of our study was to estimate the changes of superoxide dismutase (both isoenzymes: SOD-Zn, Cu and SOD-Mn in serum and total activity in erythrocytes) and gluthatione peroxidase (in erythrocytes) activities in newly diagnosed carbohydrate metabolism disturbances. 80 subjects were divided into two groups: the control with normal oral tolerance glucose test (OGTT) (n = 44) and investigated group (concentration of fasting glucose over 6.1 mmol/l and/or concentration of glucose in second hour of OGTT over 7.8 mmol/l) (n = 36). No differences of superoxide dismutase and gluthatione peroxidase activities as well as negative correlation between gluthatione peroxidase activity and concentration of glucose in second hour of OGTT (R = -0.28; p = 0.032) were observed. Falling tendency of gluthatione peroxidase activity in erythrocytes in subjects with postprandial hyperglycaemia suggest that this enzyme could be an early marker of antioxidant status of carbohydrate metabolism disturbances.