RESUMO
Pulmonary involvement in HTLV-I patients has been identified by several authors in Africa, Japan and Brazil. The objective of this controlled study is to establish an association between HAM and lymphocytosis in the bronchoalveolar fluid (BAL). Thirty-five adult patients with non-traumatic and non-tumoral myelopathy filled out a detailed historical survey and underwent a neurological examination, a thoracic radiological evaluation and a CSF examination. Of the patients in this sample, 22 were diagnosed with HTLV-I associated myelopathy and 13 had myelopathies with other etiologies. Lymphocytosis in the BAL fluid was detected in 18 (82%) of the HAM patients and in 2 (15%) of non-HAM patients. We concluded that the lung represents an important organ in the pathogenesis of HAM.
Assuntos
Líquido da Lavagem Broncoalveolar/citologia , Pneumopatias/virologia , Paraparesia Espástica Tropical/virologia , Adulto , Idoso , Brasil , Líquido da Lavagem Broncoalveolar/virologia , Anticorpos Antideltaretrovirus , Humanos , Pessoa de Meia-Idade , Paraparesia Espástica Tropical/sangue , Paraparesia Espástica Tropical/líquido cefalorraquidiano , Paraparesia Espástica Tropical/imunologia , Testes de Função RespiratóriaRESUMO
Mielopatia por HTLV-I (HAM) tem sido descrita como doença sistêmica caracterizada pelo acometimento de vários órgäos além do sistema nervoso. Neste registro, estamos relatando o envolvimento pulmonar em pacientes com HAM
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Linfocitose/complicações , Paraparesia Espástica Tropical/complicações , Fibrose Pulmonar/complicações , Centrifugação , Líquido da Lavagem Broncoalveolar/patologia , Linfocitose/patologia , Fibrose Pulmonar/patologiaRESUMO
HTLV-I associated myelopathy has been described as a systemic disease characterized by manifestations in several organs outside the nervous system. We report inflammatory pulmonary involvement in patients with diagnosis of HAM.
