RESUMO
In 45 experimental rabbits, subjected to trans-carotid aorto-valvulotomy in a month developed a congestive heart failure. When this group of rabbits was compared to the control group of 20 animals, in the course of complete pathomorphologic, histochemical and stereomorphologic analysis the following results were obtained: potassium oroticum did not show any efficacy at all; the efficacy of taurine in a dose of 10 mg/kg was low. Its effect was both direct and indirect acting through the autonomic nervous system.
Assuntos
Insuficiência da Valva Aórtica/tratamento farmacológico , Taurina/uso terapêutico , Animais , Valva Aórtica/patologia , Insuficiência da Valva Aórtica/patologia , Coração/efeitos dos fármacos , Coração/fisiopatologia , Insuficiência Cardíaca/tratamento farmacológico , Insuficiência Cardíaca/patologia , Hemodinâmica , Masculino , Miocárdio/patologia , Coelhos , Taurina/administração & dosagemRESUMO
The spasmolysant fenicaberane was found to induce diverse changes in electrolyte levels, a significant increase of lactate content in all vascular zones, various changes in pyruvate levels depending on the vascular tissue type.
Assuntos
Benzofuranos/farmacologia , Vasos Sanguíneos/efeitos dos fármacos , Metabolismo dos Carboidratos , Parassimpatolíticos/farmacologia , Animais , Vasos Sanguíneos/metabolismo , Gatos , Eletrólitos/metabolismo , Feminino , Lactatos/metabolismo , Ácido Láctico , Masculino , NAD/metabolismo , Oxirredução , Piruvatos/metabolismo , Ácido PirúvicoRESUMO
6-month hypercholesterol diet made it possible to obtain an adequate model of atherosclerosis in inbred rats. The model was characterized by lipoidosis and fibrous plaques which occupied half of the area of the aorta and coronary arteries, as well as secondary fibrosis of other organs. During atherogenesis changes in endothelial and myocyte cells appear, accumulation of acid glycosaminoglycans takes place, lipoidosis and elastofibrosis progress up to collagenization and hyalinosis of the arterial wall. Fibro-myocyte plaques are transformed into fibro-atheromatous plaques. Upon drug therapy with vegetative saponins and furastonolic glycosides fibrous lesions did not regress, but delipidization and translocation of glycosaminoglycans were observed in 30% of the area of the affected arteries, and elastofibrosis and changes in endothelial and myocyte cells were decreased. Long-term therapy with vegetative drugs produced a regression of the experimental atherosclerosis.