Detección precoz del cáncer de próstata. ¿Beneficios de su inclusión en el protocolo de vigilancia de la salud? / Precocious detection of the prostate cancer. Benefits of its inclusion in the protocol of monitoring of the health?

Aunque el cáncer de próstata afecta fundamentalmente a hombres de edad avanzada, alrededor del 25% se diagnostican antes de los 65 años. La técnica de cribado que se ha demostrado de mayor utilidad es la determinación del Antígeno Prostático Específico (PSA). Su relación con el PSA libre discrimina la patología benigna de las de origen tumoral. Objetivo: Conocer la prevalencia de patología prostática entre los de trabajadores de la Diputación Provincial de Cádiz. Material y método: Como parte del protocolo de vigilancia de la salud realizado por el Servicio de Prevención y Salud Laboral se incluye la realización de Ecografía Abdominal/ Prostática y la determinación de PSA en varones mayores de 50 años. Participaron en el estudio un total de 229 trabajadores a los que también se les realizó una encuesta autoadministrada sobre «patología urológica». Tipo de estudio: Descriptivo-observacional. Resultados: Media de edad: 61,07 años (DS 5,95). Los valores del PSA fueron inferiores a 4ng/ml en el 92,14%, en el 5,71% presentaron valores entre 4-10 ng/ml, y el 2,14% presentó valores superiores a 10 ng/ml. De los 152 trabajadores que se realizaron ecografía abdominal, en 21 casos (13,82%) se detectó la presencia de un nódulo prostático

Although the prostate cancer fundamentally affects to age men older, around 25% are diagnosed before the 65 years. The sifting technique that has been demonstrated of greater utility is the determination of Prostate Specific Antigen (PSA). Its relation with the PSA frees discriminates the benign pathology of those of tumour like origin. Objective: To know the prevalence prostate pathology between those of workers of the Provincial Delegation of Cadiz. Measurement: As it leaves from the protocol of monitoring of the health made by the Service of Prevention and Labour Health include the accomplishment of Ultrasound Abdominal/Prostates and the determination of PSA in greater men of 50 years. A total of 229 workers participated in the study to whom also a survey on «urology pathology» was made to them. Desingn: Descriptive observacional study. Results: Age Average: 61.07 years (DS 5.95) the values of the PSA were inferior to 4ng/ml in 92.14%, in 5.71% they presented/displayed values between 4-10 ng/ml, and 2.14% presented/displayed 10 values superior to ng/ml. Of the 152 workers who were made abdominal ultrasound, in 21 cases (13,82%) the presence of a prostate nodule was detected

[Cholestatic hepatitis caused by midecamycin]. / Hepatitis colestásica por midecamicina.

Hepatotoxicity by macrolide antibiotics, particularly erythromycin and derivatives, is a side effect extensively described in the literature. Midecamycin is a semi-synthetic derivative of this family with a wide safety margin of which isolated references of possible secondary hepatobiliary effects have been referred. The present clinical observation describes a case of cholestatic hepatitis which, in our opinion, was related to the administration of diacetyl midecamycin which evolved favorably following discontinuation of the drug. Despite its exceptional frequency and based on the wide therapeutic diffusion of this group of antibiotics, we believe this case to be of interest.