La depresión: un predictor de demencia / Depression: a predictor of dementia

Algunos estudios sugieren que hasta un tercio de los casos de Alzheimer, la demencia más común en nuestra sociedad, puede ser prevenido con la eliminación de algunos factores de riesgo. Barnes y Yaffe encontraron que un 10% de casos de Alzheimer eran atribuibles a la depresión, pero en la literatura científica no queda claro su papel etiológico en el desarrollo de demencia. El objetivo de la revisión es analizar la evidencia científica sobre la hipótesis de que la depresión aumenta el riesgo de desarrollar demencia. Se realizó una revisión sistemática y metaanálisis con literatura científica publicada hasta la fecha, con una cobertura temporal entre 1990 y 2014. Diez de los artículos encontrados cumplían con los criterios de selección -similitud en a) tamaño y características de la muestra (procedencia, edad…), b) procedimiento de recogida de datos, c) método de estudio de la relación (comparación inter- como intragrupal), d) método estadístico de análisis de los resultados- y calidad previamente establecidos. Los valores de odds ratio de los estudios analizados oscilan entre 1,72 y 3,59, y los de hazard ratio de entre 1,72 a 5,44, lo que indica que los sujetos con historia de depresión tienen mayor riesgo de desarrollar demencia que aquellos que no la han tenido (AU)

Many studies suggest that in 10-25% of cases of Alzheimer's, the most common dementia in our society, can be prevented with the elimination of some risk factors. Barnes and Yaffe found that one-third of Alzheimer's cases are attributable to depression, but in the scientific literature it is not clear if it has a real causal effect on the development of dementia. The purpose of this study is to analyse the scientific evidence on the hypothesis that depression increases the risk of developing dementia. A systematic review and a meta-analysis were performed on the scientific literature published up until the present day, searching articles that were published between 1990 and 2014. Ten of the studies found met the selection criteria -similar to a) size and characteristics of the sample (origin, age…), b) process of gathering data c) method of studying the relationship (within and/or between group comparison), and d) statistical analysis of the results- and the previously established quality. The value of odds ratio varied from 1.72 to 3.59, and the hazard ratio from 1,72 to 5.44. This indicates that the subjects with a history of depression have a higher risk of developing dementia than others who did not suffer depression (AU)

[Depression: A predictor of dementia]. / La depresión: un predictor de demencia.

Many studies suggest that in 10-25% of cases of Alzheimer's, the most common dementia in our society, can be prevented with the elimination of some risk factors. Barnes and Yaffe found that one-third of Alzheimer's cases are attributable to depression, but in the scientific literature it is not clear if it has a real causal effect on the development of dementia. The purpose of this study is to analyse the scientific evidence on the hypothesis that depression increases the risk of developing dementia. A systematic review and a meta-analysis were performed on the scientific literature published up until the present day, searching articles that were published between 1990 and 2014. Ten of the studies found met the selection criteria -similar to a) size and characteristics of the sample (origin, age…), b) process of gathering data c) method of studying the relationship (within and/or between group comparison), and d) statistical analysis of the results- and the previously established quality. The value of odds ratio varied from 1.72 to 3.59, and the hazard ratio from 1,72 to 5.44. This indicates that the subjects with a history of depression have a higher risk of developing dementia than others who did not suffer depression.