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Med Hypotheses ; 79(4): 542-3, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22867866

RESUMO

Patients suffering from chronic intestinal diseases (Crohn's disease, Ulcerative Colitis, Indeterminate Colitis) are prone to the development of pyogenic complications. These complications are most commonly in the form of perianal or intraabdominal abscesses and/or fistulas. The treatment of these complications are managed differently but, after an initial treatment based on medical or minimally invasive management, the solution of the pathological condition is always achieved by a surgical procedure. In the last few years prospective studies have proposed an alternative conservative therapeutic approach based on application of fibrin glue in the healing of patients with fistulas-in-ano. In this paper we suggest and discuss the therapeutic potential of silver and quarz in the conservative treatment of anorectal fistulas pointing out their role in modulating particular steps of the pathogenetic process which characterizes this pathological condition.


Assuntos
Quartzo/administração & dosagem , Fístula Retal/terapia , Prata/administração & dosagem , Diferenciação Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Adesivo Tecidual de Fibrina/administração & dosagem , Fibroblastos/efeitos dos fármacos , Fibroblastos/patologia , Humanos , Modelos Biológicos , Fístula Retal/patologia , Soluções , Cicatrização/efeitos dos fármacos
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