1.
Bioorg Med Chem Lett
; 22(10): 3455-9, 2012 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22516283
RESUMO
A regioselective route to novel mono triazolyl substituted quinolines has been developed via copper-catalyzed azide-alkyne cycloaddition (CuAAC) of 2,4-diazidoquinoline with terminal alkynes in DMF. The reaction provided bis triazolyl substituted quinolines when performed in water in the presence of Et(3)N. A number of the compounds synthesized showed promising anti-proliferative properties when tested in vitro especially against breast cancer cells.