RESUMO
PURPOSE: The efficacy of i.âv. thrombolysis in acute stroke with high clot burden is limited. Successful recanalization is very unlikely if the thrombus length exceeds 7âmm. Thus this retrospective controlled study evaluated the efficacy and safety of neurothrombectomy in the treatment of acute embolic stroke in patients selected by a thrombus length of ≥â8âmm using the stent retriever Trevo(®) device. MATERIALS AND METHODS: 40 patients with acute occlusion of the anterior intracranial arteries with a thrombus length of ≥â8âmm were treated with neurothrombectomy. We compared the outcome with a historical cohort of 42 patients with a thrombus length of ≥â8âmm that received i.âv. thrombolysis only. Clinical outcome was assessed by modified Rankin scale in both groups at discharge and on day 90. RESULTS: Patients did not differ in age, mRS on admission, thrombus length or time from symptom onset to i.âv. thrombolysis, but the thrombectomy group had higher NIHSS on admission. Successful recanalization was achieved in 33/40 patients (83â%) with neurothrombectomy. 15 patients received i.âv. thrombolysis prior to neurothrombectomy. Median mRS at discharge was 3.5 (1.25â-â5) vs. 5 (4â-â6; pâ<â0.01) and on day 90 3 (1â-â4) vs. 5 (4â-â6; pâ<â0.01). Symptomatic hemorrhage occurred in 3 vs. 7 patients. 3 vs. 17 patients died within 90 days (thrombectomy vs. control each). There were only a few intervention-related complications. CONCLUSION: Thrombectomy in acute stroke with high clot burden using the Trevo(®) device has a low risk and improved clinical outcome compared to i.âv. thrombolysis alone. Treatment selection by a clot length of ≥â8âmm might be a powerful approach to improve the outcome of mechanical thrombectomy. KEY POINTS: â¢âClot length of ≥â8âmm might be a valuable criterion for indicating neurothrombectomy. â¢âThrombolysis only in high clot burden is associated with poor clinical outcome. â¢âThrombectomy using the Trevo(®) stent retriever is safe and effective.
Assuntos
Fibrinolíticos/administração & dosagem , Embolia Intracraniana/terapia , Trombólise Mecânica/instrumentação , Acidente Vascular Cerebral/terapia , Terapia Trombolítica/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Fibrinolíticos/efeitos adversos , Fibrinolíticos/uso terapêutico , Humanos , Injeções Intravenosas , Trombólise Mecânica/efeitos adversos , Trombólise Mecânica/métodos , Pessoa de Meia-Idade , Hemorragia Pós-Operatória/etiologia , Hemorragia Pós-Operatória/prevenção & controle , Desenho de Prótese , Estudos Retrospectivos , Índice de Gravidade de Doença , Stents , Terapia Trombolítica/efeitos adversos , Resultado do Tratamento , Adulto JovemRESUMO
In a hospital-based case-control study 29 patients with idiopathic Parkinson's disease (PD) and visual hallucinations (VH) were compared with 58 PD patients matched for age and disease duration, but without VH. VH patients had more frequently sleep disturbances and dementia, higher PD-related disability (Schwab-England scale), and took selegiline more frequently as an anti-Parkinsonian drug. The patient groups did not differ in age at PD onset, Webster score, treatment duration, dosage of any anti-Parkinsonian drug, frequency of levodopa-associated movement disorders, or measures on brain CT. After a median follow-up period of 27 months more VH patients had developed wearing-off and freezing phenomena, while their scores in the Mini Mental State Examination were lower. Nursing home placement during the follow-up period was associated with higher PD-related disability in VH patients.