RESUMO
Since the beginning of August 2011, an outbreak of hepatitis A has been detected in Estonia. The majority of laboratory-confirmed cases (n = 66) were notified between 4 August and 3 October 2011 and were linked to Viljandi county. The outbreak is still ongoing.
Assuntos
Surtos de Doenças , Hepatite A/epidemiologia , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Estônia/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto JovemAssuntos
Anticorpos Monoclonais/uso terapêutico , Doenças Autoimunes/terapia , Diabetes Mellitus Tipo 1/cirurgia , Transplante das Ilhotas Pancreáticas/fisiologia , Pancreatopatias/terapia , Receptores de Interleucina-2/imunologia , Animais , Doenças Autoimunes/imunologia , Diabetes Mellitus Tipo 1/genética , Diabetes Mellitus Tipo 1/imunologia , Transplante das Ilhotas Pancreáticas/imunologia , Pancreatopatias/imunologia , Ratos , Ratos Endogâmicos BB , Recidiva , Transplante IsogênicoRESUMO
Pancreatic islet grafts transplanted into subjects with spontaneous autoimmune diabetes are threatened by two immune responses, allograft rejection and the recurrence of autoimmune insulitis. To examine the recurrent autoimmune response to transplanted islets it is necessary to exclude islet allograft rejection. The BB rat is a unique model of spontaneous diabetes with clinical and pathological characteristics identical or similar to those found in human insulin dependent diabetes mellitus (IDDM). In this study we demonstrate permanent acceptance of histocompatible islet grafts in chemically induced diabetes and a lack of intracolony tissue antigen rejection in our BB rat colony. Therefore the vigorous destruction of transplanted BB islets in the liver of spontaneously diabetic BB rats is due to recurrence of diabetes. This recurrence can be prevented by transplantation of islets under the renal capsule. This may be important for clinical application in IDDM, particularly with regard to host and donor tissue matching.
