RESUMO
Advanced glycation endproducts (AGEs) and their receptors, receptor for advanced glycation endproducts (RAGE), are novel groups of molecules with roles in inflammation, cytokine activation, and promotion of cell growth. Recently, RAGE has been implicated in the progression and metastasis of several epithelial tumors. The expression of RAGE was examined in 38 oral squamous cell carcinoma (OSCC) cases by immunohistochemistry. In the OSCCs, RAGE positivity, interpreted as more than 25% positive cells, was detected in 10 of 10 well-differentiated, 3 of 4 well-to-moderately differentiated, 3 of 9 moderately differentiated, 1 of 7 moderate-to-poorly differentiated, and 0 of 8 poorly differentiated tumors. The staining percentage was significantly higher in well-differentiated tumors compared to moderately (P < .05) and poorly differentiated (P < .05) tumors. All normal mucosa samples were RAGE-positive. Western blot analysis for RAGE was performed on 2 OSCCs and 2 normal oral mucosa samples. Higher expression was observed in the normal tissues compared to the OSCCs. Our results show that RAGE immunoreactivity correlates with histologic differentiation in OSCC.
Assuntos
Carcinoma de Células Escamosas/metabolismo , Produtos Finais de Glicação Avançada/metabolismo , Neoplasias Bucais/metabolismo , Receptores Imunológicos/biossíntese , Adulto , Idoso , Idoso de 80 Anos ou mais , Western Blotting , Carcinoma de Células Escamosas/patologia , Estudos de Casos e Controles , Diferenciação Celular , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/metabolismo , Neoplasias Bucais/patologia , Antígeno Nuclear de Célula em Proliferação/biossíntese , Receptor para Produtos Finais de Glicação Avançada , Estudos RetrospectivosRESUMO
An unusual case of canalicular adenomas appearing bilaterally and simultaneously as separate nodules of the right and left upper lip is described. Upon histological examination, both nodules revealed tumor islands within their respective capsules, as well as outside their capsules and extending into normal salivary gland tissues. The article describes this unusual case and reviews the significance of the extracapsular tumor islands. The immunohistochemical profiles of canalicular adenoma and other salivary gland neoplasms with similar histology are compared and discussed.
Assuntos
Adenoma/patologia , Neoplasias Labiais/patologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares Menores/patologia , Idoso , Feminino , Humanos , Imuno-HistoquímicaRESUMO
BACKGROUND: Myeloid sarcoma is an extramedullary malignancy of myeloblasts. An unusual case of myeloid sarcoma presenting in the gingiva and affected by drug-induced gingival enlargement is presented. METHODS: A 63-year-old male taking amlodipine for his hypertension presented with a 3-week gingival enlargement. Although the obvious clinical impression was that of drug-induced gingival enlargement, an incisional biopsy was performed to corroborate chemical enlargement while ruling out diseases such as lymphoma and leukemia. RESULTS: Microscopic examination of the thickened gingiva revealed surface stratified squamous epithelium having needle-like rete pegs characteristic of drug-induced gingival enlargement. Beneath the surface epithelium, the fibrous tissue was virtually replaced by a dense infiltrate of malignant cells. Immunohistochemical studies were performed with CD117 and myeloperoxidase identifying the malignant cell population as myeloblasts, leading to a diagnosis of myeloid sarcoma. CONCLUSION: Myeloid sarcoma and hematopoietic malignancies must be included in a differential diagnosis of gingival enlargement until the definitive diagnosis is reached by histologic/laboratory examination.
