[A new method of purification of L-lysine-alpha-oxidase from the fungus Trichoderma]. / Novyi metod ochistki L-lizin-alpha-oksidazy griba Trichoderma.

A new procedure is developed for purification of the antitumoral enzyme L-lysyl-alpha-oxidase from Trichoderma sp. The procedure included two steps: hydrophobic chromatography on butyl sylochrome C-80 and chromatography using biospecific sorbent AH-Sepharose. The simplified procedure enabled to increase distinctly the specific enzymatic activity from 30 to 50 IU/mg in the preparation obtained with a good yield.

[Evaluation of antileukemic activity of L-lysine-alpha oxidase from Trichoderma sp. in chemotherapeutic experiments]. / Otsenka protivoleikoznoi aktivnosti L-lizin-alfa-oksidaza iz Trichoderma sp. v khimioterapevticheskikh opytakh.

Evidences on the antileukemic effect of L-lysine alpha-oxidase from Trichoderma sp. are presented. It is inferred that enzyme needs detail studying as a potential chemotherapeutic drug both in experimental and clinical research.