1.
Arch Int Pharmacodyn Ther
; 216(2): 280-7, 1975 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1180618
RESUMO
The effect of diazepam and/or ethanol treatment of seven days on the drug metabolizing enzymes in rat liver microsomes was studied. Diazepam decreased the metabolism rate of 3,4-benzpyrene by 38% and that of p-nitrobenzoic acid by 15%. Ethanol increased the metabolism rate of N-methylaniline by 15% and decreased the reduction of p-nitrobbenzoic acid by 48%. Although diazepam alone had no inducing effect, its use with ethanol increased the cytochrome P-450 content (56%) and the rate of metabolism of N-methylaniline (44%) more than ethanol alone. The rate of metabolism of diazepam was not affected by any treatment.
Assuntos
Diazepam/farmacologia , Etanol/farmacologia , Fígado/enzimologia , Compostos de Anilina/metabolismo , Animais , Benzopireno Hidroxilase/metabolismo , Peso Corporal/efeitos dos fármacos , Sistema Enzimático do Citocromo P-450/metabolismo , Diazepam/metabolismo , Fígado/metabolismo , Masculino , Nitrobenzoatos/metabolismo , Tamanho do Órgão/efeitos dos fármacos , Oxirredução , Oxirredutases N-Desmetilantes , Ratos
2.
Am J Obstet Gynecol
; 109(7): 1011-6, 1971 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-5549341