RESUMO
Helicobacter pylori (Hp) eradication in peptic ulcer disease is associated with a greatly reduced recurrence rate. The optimal drug regimen for HP eradication remains uncertain. It is also unclear if eradication of Hp in duodenitis and antral gastritis improves symptoms. The aims of this study were to compare the efficacy of three drug regimens in the eradication of Hp and to assess if Hp eradication improved symptoms in patients with duodenitis and antral gastritis. Patients (n = 79) found to have duodenal ulcer, duodenitis and/or antral gastritis with a positive urease test (CLO) at endoscopy were allocated to one of the three regimens: A. omeprazole 20 mg b.d. and clarithromycin 500 mg t.d.s. for two weeks (n = 27), B. De-Nol 240 mg b.d. for four weeks, metronidazole 400 mg t.d.s. and amoxicillin 500 mg t.d.s. for one week (n = 26), and C. omeprazole 20 mg b.d. and amoxicillin 500 mg t.d.s. for two weeks (n = 26). In conclusion, traditional 'triple' therapy with bismuth and two antibiotics achieved the highest Hp eradication rate and was best tolerated. Recolonisation with Hp was uncommon after eradication. Dyspeptic symptoms improved with Hp eradication in duodenitis and antral gastritis.
Assuntos
Duodenite/tratamento farmacológico , Gastrite/tratamento farmacológico , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori , Adulto , Idoso , Amoxicilina/uso terapêutico , Antibacterianos/uso terapêutico , Bismuto/uso terapêutico , Claritromicina/uso terapêutico , Quimioterapia Combinada , Úlcera Duodenal/tratamento farmacológico , Úlcera Duodenal/microbiologia , Duodenite/microbiologia , Feminino , Gastrite/microbiologia , Humanos , Masculino , Metronidazol/uso terapêutico , Pessoa de Meia-Idade , Omeprazol/uso terapêutico , Compostos Organometálicos/uso terapêutico , Penicilinas/uso terapêutico , Resultado do TratamentoRESUMO
Twelve analogues of 1-(substituted benzenesulphonyl)-5-oxopyrrolidine-2- carboxylic acid have been synthesized and tested for antineoplastic activity in Swiss albino mice with an Ehrlich ascites carcinoma (EAC) cell line. The values of percent inhibition of growth, both in ascitic cell count and fluid weight, have been taken as activity parameters. Quantitative structure-activity relationships (QSAR) have been studied using the LFER model. The best correlation (R2 = 93.0%) was found using molar refractivity (MR), which measures the molar volume and polarizability of the substituents.
Assuntos
Antineoplásicos/farmacologia , Desenho de Fármacos , Ácido Pirrolidonocarboxílico/farmacologia , Animais , Antineoplásicos/química , Carcinoma de Ehrlich , Ensaios de Seleção de Medicamentos Antitumorais , Camundongos , Ácido Pirrolidonocarboxílico/análogos & derivados , Ácido Pirrolidonocarboxílico/química , Relação Estrutura-AtividadeAssuntos
Amilases/sangue , Miosite/enzimologia , Adulto , Biomarcadores , Biópsia , Feminino , Humanos , Músculos/patologia , Miosite/patologiaRESUMO
The contribution of the elderly to the workload of a combined consultative District Hospital Gastroenterology Clinic has been studied over a 12-year period. The elderly group comprise 24% of the total referrals with a gradually increasing trend over successive years. The service implications are discussed and the main diagnostic categories reviewed. Particular attention is drawn to the low incidence of functional gastroenterological disorders in the elderly and the corollary that there is a high chance of an organic explanation for the presenting complaints.
