Three novel dihydrochalcones from Flemingia lineata (L.) W.T. Aiton and their antiplasmodial activity.

Three novel dihydrochalcones, flemilineatins C-E (1-3), and two known flavanones (4-5) were isolated from Flemingia lineata (L.) W.T. Aiton leaves. Dihydrochalcones 1-3 structures were established using NMR spectrum and high-resolution ESIMS data. Compounds 1-5 were assayed to Plasmodium falciparum lactate dehydrogenase (PfLDH) for their antiplasmodial activity. Compounds 2 and 5 exhibited high activity with an IC50 value of 0.74 and 0.79 µg/mL, respectively.