Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Nat Prod Res ; : 1-9, 2024 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-38230507

RESUMO

Xanthorrhizol (1) is known as the major terpenoid component of the rhizome of Curcuma xanthorrhiza and having some interesting biological activities. In this report, we synthesised five derivatives of 1 containing nitrogen-functional groups. Four of them are new synthesised compounds, including (R)-4-(3-(2-methyl-5-(6-methylhept-5-en-2-yl)phenoxy)propyl)morpholine (2), (R)-N-benzyl-3-(2-methyl-5-(6-methylhept-5-en-2-yl)phenoxy)propan-1-amine (3), (R)-6,7-dimethoxy-3-(3-(2-methyl-5-(6-methylhept-5-en-2-yl)phenoxy)propyl)quinazolin-4(3H)-one (4), and (R)-6-methyl-3-(6-methylhept-5-en-2-yl)-2-nitrophenol (5) groups. Meanwhile the other is the known compound, that is (R)-2-methyl-5-(6-methylhept-5-en-2-yl)-4-nitrophenol (6). The caspase-7 inhibitory activity of compounds 1-6 was evaluated as well. In comparison to other derivatives, compounds 5 and 6 exhibited higher activity. Consequently, compounds 5 and 6 may be a promising lead compound for further development as a caspase-7 inhibitor.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...