1.
J Org Chem
; 85(5): 3110-3124, 2020 03 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31928000
RESUMO
Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.
2.
Deoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives.
J Org Chem
; 84(24): 16105-16115, 2019 12 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31714081
RESUMO
A practical method for the synthesis of functionalized aliphatic trifluoromethyl-substituted derivatives from aliphatic acids is developed. The transformation proceeds with sulfur tetrafluoride in the presence of water as a key additive. Compared to previous methods, the reaction gives products with full retention of stereo- and absolute configuration of chiral centers.