[The clinico-immunological characteristics of ornithosis-related pneumonia]. / Kliniko-immunologicheskaia kharakteristika ornitoznoi pnevmonii.

Examination of 38 patients with pneumonic form of ornithosis revealed important immunological shifts of suppressor type secondary immuno-deficiency. The condition runs protracted course, with the pneumonic foci being observable for some length, the physical findings not remarkable. The presence of secondary immuno-deficiency suggests that conventional therapy of ornithosis provides no benefit in patients and warrants the use of immunomodulating agents to deal with the above condition.

[Immune and microhemodynamic disorders in patients with viral hepatitis and their correction]. / Immunnye i mikrogemodinamicheskie narusheniia u bol'nykh virusnym gepatitom i ikh korrektsiia.

In patients with acute viral hepatitis B (VHB) disturbances in the immune status and the state of microhemodynamics was established; the degree of their manifestation and their duration depended on the severity of the disease and the presence of clinically manifest concomitant pathology. Immune and microcirculatory disturbances were found to be pathogenetically interrelated. The inclusion of Antral into the complex therapy of 74 VHB patients contributed to the rapid normalization of their immune status and microhemodynamics, which led to the improvement of clinical characteristics, a decrease in the frequency of complications and unfavorable consequences of VHB, accelerated convalescence.

[The effect of endovascular laser therapy and antioxidants on the immune status and energy metabolism of patients with treatment-resistant forms of schizophrenia]. / Vliianie éndovaskuliarnoi lazeroterapii i antioksidantov na immunnyi status i énergeticheskii obmen u bol'nykh s resistentnymi k lecheniiu formami shizofrenii.

The influence of endovascular laser therapy and of antioxidants on clinical immunological indices and energy metabolism was analysed in 148 schizophrenic patients including 86 patients with shift-like progredient (first group) and 62 patients with continuous-progredient (second group) forms of the disease. Positive trends in psychosis course were observed in 57% of cases in the first group and in 41.9% of patients of the second group. Pronounced improvement of the immunological indices was observed in patients with positive clinical dynamics: decreased peripheral blood immunocytes sensitization to the brain, hepatic, thymus tissue antigens as well as ATP elevation which was evidence of the improvement of energy metabolism.

[Antioxidants in the treatment of schizophrenia (the correction of lipid peroxidation processes)]. / Antioksidanty v lechenii shizofrenii (korrektsiia protsessov perekisnogo okisleniia lipidov).

It was established in the course of 185 schizophrenic patients' examination that intensification of lipid peroxidation (LP) took place in relapses of the disease. It was manifested either in increase of blood serum levels of both malonic dialdehyde and diene conjugates, or in decrease of erythrocytes' resistance to LP mediated hemolysis. Alterations in indices of either spontaneous or induced chemoluminescence were revealed too. LP indices were lower by the end of the treatment in hospital, but remained significantly higher than normal values. Application of antioxidants in combined treatment of schizophrenic patients promoted decrease of LP activity as well as improvement in mental state of patients. LP activity was high in the remission too. Determination of LP indices may have prognostic importance.

[Immune status and micro-hemodynamic function of patients with chronic alcoholism and liver pathology]. / Immunnyi status i sostianie mikrogemodinamiki bol'nykh khronicheskim alkogolizmom i patologiei pecheni.

126 patients with chronic alcoholism combined with hepatic pathology (of alcoholic genesis) were examined. Laboratory immunological observations with the using of monoclonal antibodies demonstrated the expressed alterations of immune homeostasis exactly the decrease of total T-lymphocytes population (CD11+) as well as the number of T-helpers/inductors (CD40, immunoregulatory index and the increase of the level of circulating immune complexes. The correlation between the immune alterations and the microhemodynamic disturbances was also observed. In connection with the results mentioned above the question arose about application worth of both immunological correctors and angioprotectors in therapy of alcoholism espessially combined with hepatic pathology.

[Use of chemiluminescence in predicting suppurative-inflammatory complications in erysipelas and tonsillitis]. / Primenenie khemiliuminestsentsii dlia prognozirovaniia gnoino-vospalitel'nykh oslozhnenii pri rozhe i angine.

The levels of spontaneous and induced chemiluminescence of whole blood were assessed in 165 patients with erysipelas in the acute period of the infection and in 129 patients followed up for 1 to 6 months after it, as well as in 216 patients with tonsillitis in the acute period of the infection and in 182 ones after it. Induced chemiluminescence was 4-5 times more intensive than spontaneous one in the acute period of streptococcal infections (erysipelas, tonsillitis) during the development of pyo-inflammatory complications; when the disease course was uncomplicated, this difference made up 2.6-3.2 times. During remission of streptococcal infections (in case of recurrences or exacerbations) the initial level of spontaneous chemiluminescence was significantly lowered as against the norm, and the intensity of induced chemiluminescence was 2.35 +/- 0.12 times higher, the normal value being 2.83 +/- 0.15.

[Use of vilozen and ketotifen combination for increasing the effectiveness and prevention of complications of antibiotic therapy of streptococcal infections]. / Primenenie kombinatsii vilozena i ketotifena dlia povysheniia éffektivnosti i profilaktiki oslozhnenii antibiotikoterapii streptokokkovykh infektsii.

The clinical efficacy of a vilozen and ketotifen (zaditen) combination in the treatment of streptococcal infections along with the routine therapy was studied. The use of the combination was shown advisable in the complex therapy and prevention of relapses in patients with streptococcal infections. The combined pharmacotherapy promoted better clinical indices, normalization of the immune status and a reduction in the incidence of allergic reactions to antibiotics and a decrease in sensitization to bacterial allergens.

[Combined chemotherapy of toxic hepatitis in patients with pulmonary tuberculosis]. / Kombinirovannaia farmakoterapiia toksicheskikh gepatitov u bol'nykh tuberkulezom legkikh.

The follow-up involved patients with infiltrative pulmonary tuberculosis who developed toxic medicamentous hepatitis associated with antituberculosis drugs. They were treated by the method of combined pharmacotherapy which comprised sodium nucleinate (0.5 g 4 times daily), splenin (2 ml twice a day) and quercetin. The given combination of drugs rapidly improved clinical parameters and normalized immunologic tests.

[The immunocorrective therapy of patients with viral hepatitis A living under the adverse conditions of an industrial region]. / Immunokorrigiruiushchaia terapiia bol'nykh virusnym gepatitom A, prozhivaiushchikh v usloviiakh neblagopriiatnogo promyshlennogo regiona.

A study is presented of 356 patients with viral hepatitis A (age: 16-35 years); 256 of them lived in a zone of industrially caused contaminations of the atmospheric air and 100 (control group) lived in rural districts. Of the main group 106 patients were given during the acute period basis treatment plus quercetin, splenin, sodium nucleinate and glyciram. It was found that in those living in ecologically unfavourable regions viral hepatitis A had a more severe course, the disease was protracted, recurrences were more frequent, immune disorders were pronounced and long-standing. Use of immunocorrective and hepatoprotecting treatment resulted in an essential improvement of the clinical and immunological indices.