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1.
Clin Infect Dis ; 76(6): 1022-1029, 2023 03 21.
Artigo em Inglês | MEDLINE | ID: mdl-36358021

RESUMO

BACKGROUND: This prospective study characterizes the structural and metabolic cerebral correlates of cognitive impairments found in a preclinical setting that considers the lifestyle of young European men exposed to human immunodeficiency virus (HIV), including recreational drugs. METHODS: Simultaneous structural brain magnetic resonance imaging (MRI) and positron emission tomography using [18F]-fluorodeoxyglucose (FDG-PET) were acquired on a hybrid PET-MRI system in 23 asymptomatic young men having sex with men with HIV (HIVMSM; mean age, 33.6 years [range, 23-60 years]; normal CD4+ cell count, undetectable viral load). Neuroimaging data were compared with that of 26 young seronegative men under HIV preexposure prophylaxis (PrEPMSM), highly well matched for age and lifestyle, and to 23 matched young seronegative men (controls). A comprehensive neuropsychological assessment was also administered to the HIVMSM and PrEPMSM participants. RESULTS: HIVMSM had lower performances in executive, attentional, and working memory functions compared to PrEPMSM. No structural or metabolic differences were found between those 2 groups. Compared to controls, HIVMSM and PrEPMSM exhibited a common hypometabolism in the prefrontal cortex that correlated with the level of recreational drug use. No structural brain abnormality was found. CONCLUSIONS: Abnormalities of brain metabolism in our population of young HIVMSM mainly relate to recreational drug use rather than HIV per se. A complex interplay between recreational drugs and HIV might nevertheless be involved in the cognitive impairments observed in this population.


Assuntos
Disfunção Cognitiva , Infecções por HIV , Drogas Ilícitas , Masculino , Humanos , Adulto , HIV , Drogas Ilícitas/efeitos adversos , Drogas Ilícitas/metabolismo , Estudos Prospectivos , Cognição , Encéfalo/diagnóstico por imagem , Encéfalo/patologia , Disfunção Cognitiva/patologia , Fluordesoxiglucose F18/metabolismo , Imageamento por Ressonância Magnética , Tomografia por Emissão de Pósitrons , Infecções por HIV/patologia , Testes Neuropsicológicos
2.
Front Aging Neurosci ; 13: 711375, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34475819

RESUMO

The Free and Cued Selective Reminding Test (FCSRT) is a largely validated neuropsychological test for the identification of amnestic syndrome from the early stage of Alzheimer's disease (AD). Previous electrophysiological data suggested a slowing down of the alpha rhythm in the AD-continuum as well as a key role of this rhythmic brain activity for episodic memory processes. This study therefore investigates the link between alpha brain activity and alterations in episodic memory as assessed by the FCSRT. For that purpose, 37 patients with altered FCSRT performance underwent a comprehensive neuropsychological assessment, supplemented by 18F-fluorodeoxyglucose positron emission tomography/structural magnetic resonance imaging (18FDG-PET/MR), and 10 min of resting-state magnetoencephalography (MEG). The individual alpha peak frequency (APF) in MEG resting-state data was positively correlated with patients' encoding efficiency as well as with the efficacy of semantic cues in facilitating patients' retrieval of previous stored word. The APF also correlated positively with patients' hippocampal volume and their regional glucose consumption in the posterior cingulate cortex. Overall, this study demonstrates that alterations in the ability to learn and store new information for a relatively short-term period are related to a slowing down of alpha rhythmic activity, possibly due to altered interactions in the extended mnemonic system. As such, a decreased APF may be considered as an electrophysiological correlate of short-term episodic memory dysfunction accompanying pathological aging.

3.
J Sleep Res ; 28(4): e12798, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30485575

RESUMO

Performance for controlled, resource-demanding retrieval in episodic memory has been consistently found to be better at an optimal compared with non-optimal time of the day, evidencing a synchrony effect. However, performance in memory tasks in which retrieval is mostly based on automatic processes was inconclusively found either to be better at a non-optimal time of day or independent of synchrony effects. A caveat in most prior studies is that optimal/non-optimal time of day is based on morningness-eveningness composite scores derived from chronotype questionnaires, which might not efficiently predict subjectively-defined cognitive efficiency periods. An additional caveat is that separate tasks are used to assess explicit and implicit retrieval in verbal memory. Indeed, no task is process-pure, and both controlled and automatic retrieval processes may potentially contribute to retrieval scores in different types of memory tasks. In the present study, we investigated the impact of individually defined subjective optimal/non-optimal time of day on verbal memory retrieval, using an adaptation of the Process-Dissociation Procedure that allows estimating the respective contributions of automatic and controlled memory retrieval processes within the same memory task. Our results disclose a higher involvement of controlled processes at subjectively optimal compared with non-optimal time of day, but no differences for automatic processes. Synchrony effects and subjectively-defined peaks and troughs of performance for controlled components of memory retrieval should be considered in the evaluation of episodic memory.


Assuntos
Armazenamento e Recuperação da Informação/métodos , Memória Episódica , Adulto , Ritmo Circadiano , Feminino , Humanos , Masculino , Tempo de Reação , Inquéritos e Questionários , Adulto Jovem
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