RESUMO
A recent meta-analysis observed a greater significant inverse association of the ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) for Asian (predominantly Japanese) populations compared with Caucasian populations. We performed an independent case-control study in 335 PD and 341 control subjects with data from a Chinese population to investigate the age-of-onset effect of the UCHL1 variant in PD. The Y/Y and Y/S genotypes were less frequent in the PD young-onset group than in controls and the frequency of the Y alleles was higher in young controls compared to young-onset PD (age at examination Assuntos
Variação Genética/genética
, Genótipo
, Doença de Parkinson/genética
, Ubiquitina Tiolesterase/genética
, Adulto
, Fatores Etários
, Idoso
, Idoso de 80 Anos ou mais
, Estudos de Casos e Controles
, Humanos
, Masculino
, Pessoa de Meia-Idade
, Polimorfismo Genético/genética
, Valores de Referência
, Singapura
